A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.
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2016-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12364 |
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doaj-1d49ffd398a147089d057cbfe5d89dfe2021-05-11T10:44:38ZengNature Publishing GroupNature Communications2041-17232016-08-017111410.1038/ncomms12364A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resectionAna López-Saavedra0Daniel Gómez-Cabello1María Salud Domínguez-Sánchez2Fernando Mejías-Navarro3María Jesús Fernández-Ávila4Christoffel Dinant5María Isabel Martínez-Macías6Jiri Bartek7Pablo Huertas8Departamento de Genética, Universidad de SevillaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaDepartamento de Genética, Universidad de SevillaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaGenome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49Departamento de Genética, Universidad de SevillaGenome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49Departamento de Genética, Universidad de SevillaA DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.https://doi.org/10.1038/ncomms12364 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas |
spellingShingle |
Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection Nature Communications |
author_facet |
Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas |
author_sort |
Ana López-Saavedra |
title |
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection |
title_short |
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection |
title_full |
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection |
title_fullStr |
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection |
title_full_unstemmed |
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection |
title_sort |
genome-wide screening uncovers the role of ccar2 as an antagonist of dna end resection |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-08-01 |
description |
A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP. |
url |
https://doi.org/10.1038/ncomms12364 |
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