A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.

Bibliographic Details
Main Authors:	Ana López-Saavedra, Daniel Gómez-Cabello, María Salud Domínguez-Sánchez, Fernando Mejías-Navarro, María Jesús Fernández-Ávila, Christoffel Dinant, María Isabel Martínez-Macías, Jiri Bartek, Pablo Huertas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12364

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spelling	doaj-1d49ffd398a147089d057cbfe5d89dfe2021-05-11T10:44:38ZengNature Publishing GroupNature Communications2041-17232016-08-017111410.1038/ncomms12364A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resectionAna López-Saavedra0Daniel Gómez-Cabello1María Salud Domínguez-Sánchez2Fernando Mejías-Navarro3María Jesús Fernández-Ávila4Christoffel Dinant5María Isabel Martínez-Macías6Jiri Bartek7Pablo Huertas8Departamento de Genética, Universidad de SevillaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaDepartamento de Genética, Universidad de SevillaDepartment of Regenerative Medicine, Centro Andaluz de Biología Molecular y Medicina RegenerativaGenome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49Departamento de Genética, Universidad de SevillaGenome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49Departamento de Genética, Universidad de SevillaA DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.https://doi.org/10.1038/ncomms12364
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas
spellingShingle	Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection Nature Communications
author_facet	Ana López-Saavedra Daniel Gómez-Cabello María Salud Domínguez-Sánchez Fernando Mejías-Navarro María Jesús Fernández-Ávila Christoffel Dinant María Isabel Martínez-Macías Jiri Bartek Pablo Huertas
author_sort	Ana López-Saavedra
title	A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
title_short	A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
title_full	A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
title_fullStr	A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
title_full_unstemmed	A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
title_sort	genome-wide screening uncovers the role of ccar2 as an antagonist of dna end resection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.
url	https://doi.org/10.1038/ncomms12364
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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

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