A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.
Main Authors: | Ana López-Saavedra, Daniel Gómez-Cabello, María Salud Domínguez-Sánchez, Fernando Mejías-Navarro, María Jesús Fernández-Ávila, Christoffel Dinant, María Isabel Martínez-Macías, Jiri Bartek, Pablo Huertas |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12364 |
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