Idiopathic multicentric Castleman’s disease
Idiopathic multicentric Castlemans disease is a rare lymphoproliferative disorder that has many similar laboratory, radiological, clinical and pathological manifestations with various conditions, including IgG4-related disease. Increased activity of cytokines, especially interleukin-6, leads to syst...
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"Consilium Medicum" Publishing house
2020-06-01
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doaj-1d51dd40f7914121a68a134a20cdcace2021-01-26T09:27:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-06-01925788410.26442/00403660.2020.05.00044031135Idiopathic multicentric Castleman’s diseaseV. I. Vasilyev0S. G. Palshina1A. I. Pavlovskaya2N. V. Kokosadze3B. D. Chaltsev4L. A. Shornikova5Nasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologyBlokhin National Medical Research Center of OncologyBlokhin National Medical Research Center of OncologyNasonova Research Institute of RheumatologyYevdokimov Moscow State University of Medicine and DentistryIdiopathic multicentric Castlemans disease is a rare lymphoproliferative disorder that has many similar laboratory, radiological, clinical and pathological manifestations with various conditions, including IgG4-related disease. Increased activity of cytokines, especially interleukin-6, leads to systemic inflammatory symptoms with the development of lymphadenopathy and rarely extranodal lesions. Histological changes in the lymph nodesin hyaline vascular and plasma cell variants of Castlemans disease are hardly distinguishable from the pattern of reactive, tumor and IgG4-related lymphadenopathy. Idiopathic multicentric Castlemans disease can be diagnosed only when infection with human herpesvirus-8 type and human immunodeficiency virus is excluded. In the article, the authors describe two cases of idiopathic multicentric Castlemans disease, including the first world literature description of extranodal damage of the hip muscle in this disorder. In addition, the authors gave a review of the literature on the main clinical, laboratory and morphological manifestations, which allow confirming the diagnosis of Castlemans disease.https://ter-arkhiv.ru/0040-3660/article/viewFile/34588/pdfidiopathic multicentric castleman’s diseaselymphoproliferative diseasesigg4-related diseaseextranodal lesions in castleman’s disease. |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
V. I. Vasilyev S. G. Palshina A. I. Pavlovskaya N. V. Kokosadze B. D. Chaltsev L. A. Shornikova |
spellingShingle |
V. I. Vasilyev S. G. Palshina A. I. Pavlovskaya N. V. Kokosadze B. D. Chaltsev L. A. Shornikova Idiopathic multicentric Castleman’s disease Терапевтический архив idiopathic multicentric castleman’s disease lymphoproliferative diseases igg4-related disease extranodal lesions in castleman’s disease. |
author_facet |
V. I. Vasilyev S. G. Palshina A. I. Pavlovskaya N. V. Kokosadze B. D. Chaltsev L. A. Shornikova |
author_sort |
V. I. Vasilyev |
title |
Idiopathic multicentric Castleman’s disease |
title_short |
Idiopathic multicentric Castleman’s disease |
title_full |
Idiopathic multicentric Castleman’s disease |
title_fullStr |
Idiopathic multicentric Castleman’s disease |
title_full_unstemmed |
Idiopathic multicentric Castleman’s disease |
title_sort |
idiopathic multicentric castleman’s disease |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2020-06-01 |
description |
Idiopathic multicentric Castlemans disease is a rare lymphoproliferative disorder that has many similar laboratory, radiological, clinical and pathological manifestations with various conditions, including IgG4-related disease. Increased activity of cytokines, especially interleukin-6, leads to systemic inflammatory symptoms with the development of lymphadenopathy and rarely extranodal lesions. Histological changes in the lymph nodesin hyaline vascular and plasma cell variants of Castlemans disease are hardly distinguishable from the pattern of reactive, tumor and IgG4-related lymphadenopathy. Idiopathic multicentric Castlemans disease can be diagnosed only when infection with human herpesvirus-8 type and human immunodeficiency virus is excluded. In the article, the authors describe two cases of idiopathic multicentric Castlemans disease, including the first world literature description of extranodal damage of the hip muscle in this disorder. In addition, the authors gave a review of the literature on the main clinical, laboratory and morphological manifestations, which allow confirming the diagnosis of Castlemans disease. |
topic |
idiopathic multicentric castleman’s disease lymphoproliferative diseases igg4-related disease extranodal lesions in castleman’s disease. |
url |
https://ter-arkhiv.ru/0040-3660/article/viewFile/34588/pdf |
work_keys_str_mv |
AT vivasilyev idiopathicmulticentriccastlemansdisease AT sgpalshina idiopathicmulticentriccastlemansdisease AT aipavlovskaya idiopathicmulticentriccastlemansdisease AT nvkokosadze idiopathicmulticentriccastlemansdisease AT bdchaltsev idiopathicmulticentriccastlemansdisease AT lashornikova idiopathicmulticentriccastlemansdisease |
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1724322964748369920 |