Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the ef...
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doaj-1d52bae5e218486799926417ada22e482021-03-03T21:15:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020693410.1371/journal.pone.0206934Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.Robin BabadjouniArati PatelQinghai LiuKristina ShkirkovaKrista Lamorie-FooteMichelle ConnorDrew M HodisHank ChengConstantinos SioutasTodd E MorganCaleb E FinchWilliam J MackEpidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.https://doi.org/10.1371/journal.pone.0206934 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robin Babadjouni Arati Patel Qinghai Liu Kristina Shkirkova Krista Lamorie-Foote Michelle Connor Drew M Hodis Hank Cheng Constantinos Sioutas Todd E Morgan Caleb E Finch William J Mack |
spellingShingle |
Robin Babadjouni Arati Patel Qinghai Liu Kristina Shkirkova Krista Lamorie-Foote Michelle Connor Drew M Hodis Hank Cheng Constantinos Sioutas Todd E Morgan Caleb E Finch William J Mack Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. PLoS ONE |
author_facet |
Robin Babadjouni Arati Patel Qinghai Liu Kristina Shkirkova Krista Lamorie-Foote Michelle Connor Drew M Hodis Hank Cheng Constantinos Sioutas Todd E Morgan Caleb E Finch William J Mack |
author_sort |
Robin Babadjouni |
title |
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
title_short |
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
title_full |
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
title_fullStr |
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
title_full_unstemmed |
Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
title_sort |
nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain. |
url |
https://doi.org/10.1371/journal.pone.0206934 |
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