Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation

Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation

Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC m...

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Bibliographic Details
Main Authors: Mikhail A. Gavrilin, Christian C. McAndrew, Evan R. Prather, MuChun Tsai, Carleen R. Spitzer, Min-Ae Song, Srabani Mitra, Anasuya Sarkar, Peter G. Shields, Philip T. Diaz, Mark D. Wewers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
bronchoalveolar lavage
macrophages
inflammasomes
lung
ASC
smoking
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00461/full

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