Lymphedema and Therapeutic Lymphangiogenesis

Lymphedema and Therapeutic Lymphangiogenesis

Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, th...

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Main Authors: Yukihiro Saito, Hironori Nakagami, Yasufumi Kaneda, Ryuichi Morishita
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/804675
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spelling doaj-1d5c7f23325f437187468827fe7b87a62020-11-24T23:16:58ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/804675804675Lymphedema and Therapeutic LymphangiogenesisYukihiro Saito0Hironori Nakagami1Yasufumi Kaneda2Ryuichi Morishita3Department of Vascular Surgery, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, JapanDivision of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, and Hamamatsu University School of Medicine, 2-1 Yamadaoka, Suita, Osaka 565-0871, JapanDivision of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanLymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor.http://dx.doi.org/10.1155/2013/804675
collection DOAJ
language English
format Article
sources DOAJ
author Yukihiro Saito
Hironori Nakagami
Yasufumi Kaneda
Ryuichi Morishita
spellingShingle Yukihiro Saito
Hironori Nakagami
Yasufumi Kaneda
Ryuichi Morishita
Lymphedema and Therapeutic Lymphangiogenesis
BioMed Research International
author_facet Yukihiro Saito
Hironori Nakagami
Yasufumi Kaneda
Ryuichi Morishita
author_sort Yukihiro Saito
title Lymphedema and Therapeutic Lymphangiogenesis
title_short Lymphedema and Therapeutic Lymphangiogenesis
title_full Lymphedema and Therapeutic Lymphangiogenesis
title_fullStr Lymphedema and Therapeutic Lymphangiogenesis
title_full_unstemmed Lymphedema and Therapeutic Lymphangiogenesis
title_sort lymphedema and therapeutic lymphangiogenesis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor.
url http://dx.doi.org/10.1155/2013/804675
work_keys_str_mv AT yukihirosaito lymphedemaandtherapeuticlymphangiogenesis
AT hironorinakagami lymphedemaandtherapeuticlymphangiogenesis
AT yasufumikaneda lymphedemaandtherapeuticlymphangiogenesis
AT ryuichimorishita lymphedemaandtherapeuticlymphangiogenesis
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