Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.

Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.

Clostridium difficile intestinal disease is mediated largely by the actions of toxins A (TcdA) and B (TcdB), whose production occurs after the initial steps of colonization involving different surface or flagellar proteins. In B. subtilis, the sigma factor SigD controls flagellar synthesis, motility...

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Bibliographic Details
Main Authors: Imane El Meouche, Johann Peltier, Marc Monot, Olga Soutourina, Martine Pestel-Caron, Bruno Dupuy, Jean-Louis Pons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3865298?pdf=render

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