Cardiovascular and renal effects of hyperuricaemia and gout

• Main Authors: R. Pontremoli, G. Leoncini, F. Viazzi
• Format: Article
• Language: English
• Published: PAGEPress Publications 2012-01-01
• Series: Reumatismo
• Subjects: hyperuricaemia, gout, cv risk, kidney, organ damage.
• Online Access: http://www.reumatismo.org/index.php/reuma/article/view/567

A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease. All things considered, serum uric acid may induce cardiovascular and kidney events both directly and indirectly by promoting other well-known mechanisms of damage. While asymptomatic hyperuricemia is currently not considered to be an indication for urate lowering therapy, there is growing evidence indicating a linear relationship between pharmacological reduction in serum uric acid and incidence of cardiovascular and renal events.