Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

• Main Authors: John A. L. Meeuwsen, Marian Wesseling, Imo E. Hoefer, Saskia C. A. de Jager
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2017-07-01
• Series: Frontiers in Cardiovascular Medicine
• Subjects: inflammatory cells; coronary artery disease; biomarkers; acute coronary syndromes; stable coronary artery disease; circulating cells
• Online Access: http://journal.frontiersin.org/article/10.3389/fcvm.2017.00044/full

Atherosclerosis is a lipid driven chronic inflammatory disease underlying the majority of ischemic events such as myocardial infarction or stroke. Clinical management of ischemic events has improved considerably in the past decades. Accordingly, survival rates have increased. Nevertheless, 12% of patients die within 6 months after the initial event. To improve secondary prevention, appropriate risk prediction is key. However, up to date, there is no clinically available routine marker to identify patients at high risk for recurrent cardiovascular events. Due to the central role of inflammation in atherosclerotic lesion progression and destabilization, many studies have focused on the role of circulating inflammatory cells in these processes. This review summarizes the current evidence on the potential of circulating inflammatory cells as biomarkers for recurrent adverse manifestations in acute coronary syndrome and stable coronary artery disease patients.