Co-Targeting PIM Kinase and PI3K/mTOR in NSCLC

Co-Targeting PIM Kinase and PI3K/mTOR in NSCLC

PIM kinases are constitutively active proto-oncogenic serine/threonine kinases that play a role in cell cycle progression, metabolism, inflammation and drug resistance. PIM kinases interact with and stabilize p53, c-Myc and parallel signaling pathway PI3K/Akt. This study evaluated PIM kinase express...

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Bibliographic Details
Main Authors: Gillian Moore, Clara Lightner, Samira Elbai, Lauren Brady, Siobhan Nicholson, Ronan Ryan, Katie E. O’Sullivan, Kenneth J. O’Byrne, Carmen Blanco-Apiricio, Sinead Cuffe, Michael O’Neill, Susan Heavey, Stephen P. Finn, Kathy Gately
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
PIM kinase
PI3K-mTOR
c-Myc
drug resistance
NSCLC
tumor tissue explants
Online Access:https://www.mdpi.com/2072-6694/13/9/2139

Internet

https://www.mdpi.com/2072-6694/13/9/2139

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