Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, undersco...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16878-2 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn |
| spellingShingle |
Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis Nature Communications |
| author_facet |
Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn |
| author_sort |
Karla J. Suchacki |
| title |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_short |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_full |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_fullStr |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_full_unstemmed |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_sort |
bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, underscoring BMAT’s potential to influence systemic glucose homeostasis. |
| url |
https://doi.org/10.1038/s41467-020-16878-2 |
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doaj-1d8037faca4e43bfbbf32bcfca139cb82021-06-20T11:14:36ZengNature Publishing GroupNature Communications2041-17232020-06-0111111810.1038/s41467-020-16878-2Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasisKarla J. Suchacki0Adriana A. S. Tavares1Domenico Mattiucci2Erica L. Scheller3Giorgos Papanastasiou4Calum Gray5Matthew C. Sinton6Lynne E. Ramage7Wendy A. McDougald8Andrea Lovdel9Richard J. Sulston10Benjamin J. Thomas11Bonnie M. Nicholson12Amanda J. Drake13Carlos J. Alcaide-Corral14Diana Said15Antonella Poloni16Saverio Cinti17Gavin J. Macpherson18Marc R. Dweck19Jack P. M. Andrews20Michelle C. Williams21Robert J. Wallace22Edwin J. R. van Beek23Ormond A. MacDougald24Nicholas M. Morton25Roland H. Stimson26William P. Cawthorn27University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterDivision of Bone and Mineral Diseases, Department of Medicine, Washington UniversityEdinburgh Imaging, University of EdinburghEdinburgh Imaging, University of EdinburghUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterDipartimento di Scienze Cliniche e Molecolari, Clinica di Ematologia, Università Politecnica delle MarcheDipartimento di Scienze Cliniche e Molecolari, Clinica di Ematologia, Università Politecnica delle MarcheDepartment of Orthopaedic Surgery, Royal Infirmary of EdinburghUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterDepartment of Orthopaedics, The University of EdinburghEdinburgh Imaging, University of EdinburghDepartment of Molecular & Integrative Physiology, University of MichiganUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterUniversity/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarterBone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, underscoring BMAT’s potential to influence systemic glucose homeostasis.https://doi.org/10.1038/s41467-020-16878-2 |