Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants
Cow’s milk is the most common cause of food-protein-induced enterocolitis syndrome (FPIES). The aim of this study was to examine the clinical features and treatment outcomes of infants with severe FPIES to cow’s milk. We reviewed all infants ≤12 months of age who were hospitalized and diagnosed with...
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doaj-1d84fcf77ec34109a3ebda3b47f6abea2020-11-24T21:50:58ZengMDPI AGNutrients2072-66432015-12-0181110.3390/nu8010001nu8010001Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in InfantsMin Yang0Lanlan Geng1Zhaohui Xu2Peiyu Chen3Craig A. Friesen4Sitang Gong5Ding-You Li6Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDivision of Gastroenterology, Children’s Mercy Hospital, University of Missouri Kansas City School of Medicine, Kansas City, MO 64108, USADepartment of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDivision of Gastroenterology, Children’s Mercy Hospital, University of Missouri Kansas City School of Medicine, Kansas City, MO 64108, USACow’s milk is the most common cause of food-protein-induced enterocolitis syndrome (FPIES). The aim of this study was to examine the clinical features and treatment outcomes of infants with severe FPIES to cow’s milk. We reviewed all infants ≤12 months of age who were hospitalized and diagnosed with severe FPIES to cow’s milk between 1 January 2011 and 31 August 2014 in a tertiary Children’s Medical Center in China. Patients’ clinical features, feeding patterns, laboratory tests, and treatment outcomes were reviewed. A total of 12 infants met the inclusion criteria. All infants presented with diarrhea, edema, and hypoalbuminemia. Other main clinical manifestations included regurgitation/vomiting, skin rashes, low-grade fever, bloody and/or mucous stools, abdominal distention, and failure to thrive. They had clinical remission with resolution of diarrhea and significant increase of serum albumin after elimination of cow’s milk protein (CMP) from the diet. The majority of infants developed tolerance to the CMP challenge test after 12 months of avoidance. In conclusion, we reported the clinical experience of 12 infants with severe FPIES to cow’s milk, which resulted in malnutrition, hypoproteinemia, and failure to thrive. Prompt treatment with CMP-free formula is effective and leads to clinical remission of FPIES in infants.http://www.mdpi.com/2072-6643/8/1/1cow’s milk protein allergyfood-protein-induced enterocolitis syndromeinfants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Yang Lanlan Geng Zhaohui Xu Peiyu Chen Craig A. Friesen Sitang Gong Ding-You Li |
spellingShingle |
Min Yang Lanlan Geng Zhaohui Xu Peiyu Chen Craig A. Friesen Sitang Gong Ding-You Li Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants Nutrients cow’s milk protein allergy food-protein-induced enterocolitis syndrome infants |
author_facet |
Min Yang Lanlan Geng Zhaohui Xu Peiyu Chen Craig A. Friesen Sitang Gong Ding-You Li |
author_sort |
Min Yang |
title |
Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants |
title_short |
Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants |
title_full |
Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants |
title_fullStr |
Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants |
title_full_unstemmed |
Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants |
title_sort |
severe food protein-induced enterocolitis syndrome to cow’s milk in infants |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-12-01 |
description |
Cow’s milk is the most common cause of food-protein-induced enterocolitis syndrome (FPIES). The aim of this study was to examine the clinical features and treatment outcomes of infants with severe FPIES to cow’s milk. We reviewed all infants ≤12 months of age who were hospitalized and diagnosed with severe FPIES to cow’s milk between 1 January 2011 and 31 August 2014 in a tertiary Children’s Medical Center in China. Patients’ clinical features, feeding patterns, laboratory tests, and treatment outcomes were reviewed. A total of 12 infants met the inclusion criteria. All infants presented with diarrhea, edema, and hypoalbuminemia. Other main clinical manifestations included regurgitation/vomiting, skin rashes, low-grade fever, bloody and/or mucous stools, abdominal distention, and failure to thrive. They had clinical remission with resolution of diarrhea and significant increase of serum albumin after elimination of cow’s milk protein (CMP) from the diet. The majority of infants developed tolerance to the CMP challenge test after 12 months of avoidance. In conclusion, we reported the clinical experience of 12 infants with severe FPIES to cow’s milk, which resulted in malnutrition, hypoproteinemia, and failure to thrive. Prompt treatment with CMP-free formula is effective and leads to clinical remission of FPIES in infants. |
topic |
cow’s milk protein allergy food-protein-induced enterocolitis syndrome infants |
url |
http://www.mdpi.com/2072-6643/8/1/1 |
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