Natural Killer T Cells in Various Mouse Models of Hepatitis
Natural killer T (NKT) cells are a key component of innate immunity. Importantly, a growing body of evidence indicates that NKT cells play an integral role in various acute and chronic liver injuries. NKT cells participate in the progression of an injury through the secretion of cytokines, which pro...
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Online Access: | http://dx.doi.org/10.1155/2021/1782765 |
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doaj-1d90d30112e54789a4ff9d7b220d90ec2021-02-15T12:52:43ZengHindawi LimitedBioMed Research International2314-61332314-61412021-01-01202110.1155/2021/17827651782765Natural Killer T Cells in Various Mouse Models of HepatitisJun Guan0Gang Wang1Qin Yang2Chao Chen3Jingwen Deng4Xinyu Gu5Haihong Zhu6State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, ChinaNatural killer T (NKT) cells are a key component of innate immunity. Importantly, a growing body of evidence indicates that NKT cells play an integral role in various acute and chronic liver injuries. NKT cells participate in the progression of an injury through the secretion of cytokines, which promote neutrophil infiltration and enhance Fas ligand (FasL) and granzyme-mediated NKT cytotoxic activity. Therefore, examining the role of NKT cells in hepatic disease is critical for a comprehensive understanding of disease pathogenesis and may provide insight into novel approaches for treatment. For more than a century, mouse models that imitate the physiopathological conditions of human disease have served as a critical tool in biological and medical basic research, including studies of liver disease. Here, we review the role of NKT cells in various mouse models of hepatitis.http://dx.doi.org/10.1155/2021/1782765 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Guan Gang Wang Qin Yang Chao Chen Jingwen Deng Xinyu Gu Haihong Zhu |
spellingShingle |
Jun Guan Gang Wang Qin Yang Chao Chen Jingwen Deng Xinyu Gu Haihong Zhu Natural Killer T Cells in Various Mouse Models of Hepatitis BioMed Research International |
author_facet |
Jun Guan Gang Wang Qin Yang Chao Chen Jingwen Deng Xinyu Gu Haihong Zhu |
author_sort |
Jun Guan |
title |
Natural Killer T Cells in Various Mouse Models of Hepatitis |
title_short |
Natural Killer T Cells in Various Mouse Models of Hepatitis |
title_full |
Natural Killer T Cells in Various Mouse Models of Hepatitis |
title_fullStr |
Natural Killer T Cells in Various Mouse Models of Hepatitis |
title_full_unstemmed |
Natural Killer T Cells in Various Mouse Models of Hepatitis |
title_sort |
natural killer t cells in various mouse models of hepatitis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2021-01-01 |
description |
Natural killer T (NKT) cells are a key component of innate immunity. Importantly, a growing body of evidence indicates that NKT cells play an integral role in various acute and chronic liver injuries. NKT cells participate in the progression of an injury through the secretion of cytokines, which promote neutrophil infiltration and enhance Fas ligand (FasL) and granzyme-mediated NKT cytotoxic activity. Therefore, examining the role of NKT cells in hepatic disease is critical for a comprehensive understanding of disease pathogenesis and may provide insight into novel approaches for treatment. For more than a century, mouse models that imitate the physiopathological conditions of human disease have served as a critical tool in biological and medical basic research, including studies of liver disease. Here, we review the role of NKT cells in various mouse models of hepatitis. |
url |
http://dx.doi.org/10.1155/2021/1782765 |
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