Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils

Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils

Abstract Cervical cancer is the last stage of a series of molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses and evasion mechanisms, which culminates with tolerance toward tumor antigens. Our objective was to understand local...

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Bibliographic Details
Main Authors: Karla Lucia Fernandez Alvarez, Mariana Beldi, Fabiane Sarmanho, Renata Ariza Marques Rossetti, Caio Raony Farina Silveira, Giana Rabello Mota, Maria Antonieta Andreoli, Eliana Dias de Carvalho Caruso, Marcia Ferreira Kamillos, Ana Marta Souza, Haydee Mastrocalla, Maria Alejandra Clavijo-Salomon, José Alexandre Marzagão Barbuto, Noely Paula Lorenzi, Adhemar Longatto-Filho, Edmund Baracat, Rossana Verónica Mendoza Lopez, Luisa Lina Villa, Maricy Tacla, Ana Paula Lepique
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09079-3

Internet

https://doi.org/10.1038/s41598-017-09079-3

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