Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial
Background and Aim: The purpose of this study was to evaluate the effects of probiotic and alpha-lipoic acid (ALA) supplements, on appetite in overweight people. Materials and Methods: This study included two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight...
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Kurdistan University of Medical Sciences
2020-09-01
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doaj-1da43e95b2c148318264813f86c34ef72020-12-22T07:34:35Zfas Kurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402020-09-01254119Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trialGholamreza Nasiri0Ali Bastani1Ali Akbar Haji-Aghamohammadi2Mohamadreza Rashidi Noosh abadi3Parviz Shahmirzalou4Hossein Khadem Haghighian5 Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran Department of Internal Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. ORCID ID: 0000-0002- 5434-4939 Department of Internal Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Biostatistics, Khoy university of Medical Sciences, West Azerbaijan, Iran Department of Nutrition, School of Health, Qazvin University of Medical Science, Qazvin, Iran Background and Aim: The purpose of this study was to evaluate the effects of probiotic and alpha-lipoic acid (ALA) supplements, on appetite in overweight people. Materials and Methods: This study included two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight people were randomly divided into 4 groups: Isocaloric diet with probiotic (500mg), isocaloric diet with ALA (600mg) and probiotic, isocaloric diet with ALA and isocaloric diet with placebo groups. In the second phase, the participants received normal diet with the above - mentioned supplements. At the beginning and end of the first phase and at the end of the second phase, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, C-reactive protein (CRP), and appetite were evalauted. We used SPSS software for statistical analysis. Independent sample t-test and ANOVA were used to compare the alterations in the mean values among the groups. Results: At the end of the first phase, the level of anthropometric changes, inflammatory factor and appetite were significant in the intervention groups, but these changes were higher in the probiotic + ALA group than in the other groups (P <0.05). At the end of the second phase we found significant changes only in the probiotic + ALA group (P<0.05). Conclusion: Addition of probiotic and ALA supplements to the normal diet can be effective in appetite and weight management and also maintainance of weight loss which may be due to decreased inflammation.http://sjku.muk.ac.ir/article-1-5422-en.htmlprobioticalpha lipoic acidappetiteoverweight |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Gholamreza Nasiri Ali Bastani Ali Akbar Haji-Aghamohammadi Mohamadreza Rashidi Noosh abadi Parviz Shahmirzalou Hossein Khadem Haghighian |
spellingShingle |
Gholamreza Nasiri Ali Bastani Ali Akbar Haji-Aghamohammadi Mohamadreza Rashidi Noosh abadi Parviz Shahmirzalou Hossein Khadem Haghighian Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial مجله علمی دانشگاه علوم پزشکی کردستان probiotic alpha lipoic acid appetite overweight |
author_facet |
Gholamreza Nasiri Ali Bastani Ali Akbar Haji-Aghamohammadi Mohamadreza Rashidi Noosh abadi Parviz Shahmirzalou Hossein Khadem Haghighian |
author_sort |
Gholamreza Nasiri |
title |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial |
title_short |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial |
title_full |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial |
title_fullStr |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial |
title_full_unstemmed |
Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: A double blind randomized clinical trial |
title_sort |
effects of probiotic and alpha-lipoic acid supplements, separately or in combination on appetite in overweight individuals: a double blind randomized clinical trial |
publisher |
Kurdistan University of Medical Sciences |
series |
مجله علمی دانشگاه علوم پزشکی کردستان |
issn |
1560-652X 2345-4040 |
publishDate |
2020-09-01 |
description |
Background and Aim: The purpose of this study was to evaluate the effects of probiotic and alpha-lipoic acid (ALA) supplements, on appetite in overweight people.
Materials and Methods: This study included two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight people were randomly divided into 4 groups: Isocaloric diet with probiotic (500mg), isocaloric diet with ALA (600mg) and probiotic, isocaloric diet with ALA and isocaloric diet with placebo groups. In the second phase, the participants received normal diet with the above - mentioned supplements. At the beginning and end of the first phase and at the end of the second phase, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, C-reactive protein (CRP), and appetite were evalauted. We used SPSS software for statistical analysis. Independent sample t-test and ANOVA were used to compare the alterations in the mean values among the groups.
Results: At the end of the first phase, the level of anthropometric changes, inflammatory factor and appetite were significant in the intervention groups, but these changes were higher in the probiotic + ALA group than in the other groups (P <0.05). At the end of the second phase we found significant changes only in the probiotic + ALA group (P<0.05).
Conclusion: Addition of probiotic and ALA supplements to the normal diet can be effective in appetite and weight management and also maintainance of weight loss which may be due to decreased inflammation. |
topic |
probiotic alpha lipoic acid appetite overweight |
url |
http://sjku.muk.ac.ir/article-1-5422-en.html |
work_keys_str_mv |
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