A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

Summary: The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that restrict it to native conformers. Acting after endoplasmic reticulum (ER)-resident chaperones, ERp44 retrieves its clients from downstream com...

Full description

Bibliographic Details
Main Authors: Tiziana Tempio, Andrea Orsi, Daria Sicari, Caterina Valetti, Edgar Djaha Yoboue, Tiziana Anelli, Roberto Sitia
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:iScience
Subjects:
Biological Sciences
Biochemistry
Molecular Biology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002121

Similar Items

Similar Items