Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis

Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tanger...

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Main Authors: Tsukasa Tominari, Michiko Hirata, Chiho Matsumoto, Masaki Inada, Chisato Miyaura
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319304839
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spelling doaj-1db27f13262049ad82ef8c7f8909fe1f2020-11-24T22:00:36ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011194390394Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for PeriodontitisTsukasa Tominari0Michiko Hirata1Chiho Matsumoto2Masaki Inada3Chisato Miyaura4Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, JapanDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, JapanDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, JapanDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, JapanCooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan; Corresponding author. miyaura@cc.tuat.ac.jp on July 31, 2012 (in advance)Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NFκB ligand–induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss. Keywords:: polymethoxy flavonoid, inflammatory bone resorption, periodontal diseasehttp://www.sciencedirect.com/science/article/pii/S1347861319304839
collection DOAJ
language English
format Article
sources DOAJ
author Tsukasa Tominari
Michiko Hirata
Chiho Matsumoto
Masaki Inada
Chisato Miyaura
spellingShingle Tsukasa Tominari
Michiko Hirata
Chiho Matsumoto
Masaki Inada
Chisato Miyaura
Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
Journal of Pharmacological Sciences
author_facet Tsukasa Tominari
Michiko Hirata
Chiho Matsumoto
Masaki Inada
Chisato Miyaura
author_sort Tsukasa Tominari
title Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
title_short Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
title_full Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
title_fullStr Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
title_full_unstemmed Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
title_sort polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2012-01-01
description Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the antiinflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NFκB ligand–induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss. Keywords:: polymethoxy flavonoid, inflammatory bone resorption, periodontal disease
url http://www.sciencedirect.com/science/article/pii/S1347861319304839
work_keys_str_mv AT tsukasatominari polymethoxyflavonoidsnobiletinandtangeretinpreventlipopolysaccharideinducedinflammatorybonelossinanexperimentalmodelforperiodontitis
AT michikohirata polymethoxyflavonoidsnobiletinandtangeretinpreventlipopolysaccharideinducedinflammatorybonelossinanexperimentalmodelforperiodontitis
AT chihomatsumoto polymethoxyflavonoidsnobiletinandtangeretinpreventlipopolysaccharideinducedinflammatorybonelossinanexperimentalmodelforperiodontitis
AT masakiinada polymethoxyflavonoidsnobiletinandtangeretinpreventlipopolysaccharideinducedinflammatorybonelossinanexperimentalmodelforperiodontitis
AT chisatomiyaura polymethoxyflavonoidsnobiletinandtangeretinpreventlipopolysaccharideinducedinflammatorybonelossinanexperimentalmodelforperiodontitis
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