Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats
The biomechanical parameters of muscle soleus contraction in rats and their blood biochemical indicators after the intramuscular administration of water-soluble C<sub>60</sub> fullerene at doses of 0.5, 1, and 2 mg/kg 1 h before the onset of muscle ischemia were investigated. In particul...
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doaj-1db4797fa2fb47749404d2374c5e6efa2021-07-15T15:36:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226812681210.3390/ijms22136812Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in RatsDmytro Nozdrenko0Tetiana Matvienko1Oksana Vygovska2Kateryna Bogutska3Olexandr Motuziuk4Natalia Nurishchenko5Yuriy Prylutskyy6Peter Scharff7Uwe Ritter8Department of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, UkraineDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, UkraineDepartment of Biology, Bogomolets National Medical University of Kyiv, 01601 Kyiv, UkraineDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, UkraineDepartment of Human and Animal Physiology, Lesya Ukrainka Volyn National University, 43025 Lutsk, UkraineDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, UkraineDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, UkraineInstitute of Chemistry and Biotechnology, Technical University of Ilmenau, 98693 Ilmenau, GermanyInstitute of Chemistry and Biotechnology, Technical University of Ilmenau, 98693 Ilmenau, GermanyThe biomechanical parameters of muscle soleus contraction in rats and their blood biochemical indicators after the intramuscular administration of water-soluble C<sub>60</sub> fullerene at doses of 0.5, 1, and 2 mg/kg 1 h before the onset of muscle ischemia were investigated. In particular, changes in the contraction force of the ischemic muscle soleus, the integrated power of the muscle, the time to achieve the maximum force response, the dynamics of fatigue processes, and the parameters of the transition from dentate to smooth tetanus, levels of creatinine, creatine kinase, lactate and lactate dehydrogenase, and parameters of prooxidant–antioxidant balance (thiobarbituric acid reactive substances, hydrogen peroxide, and reduced glutathione and catalase) were analyzed. The positive therapeutic changes in the studied biomechanical and biochemical markers were revealed, which indicate the possibility of using water-soluble C<sub>60</sub> fullerenes as effective prophylactic nanoagents to reduce the severity of pathological conditions of the muscular system caused by ischemic damage to skeletal muscles.https://www.mdpi.com/1422-0067/22/13/6812C<sub>60</sub> fullerenemuscle soleus of ratischemiabiomechanical and biochemical parameters |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dmytro Nozdrenko Tetiana Matvienko Oksana Vygovska Kateryna Bogutska Olexandr Motuziuk Natalia Nurishchenko Yuriy Prylutskyy Peter Scharff Uwe Ritter |
spellingShingle |
Dmytro Nozdrenko Tetiana Matvienko Oksana Vygovska Kateryna Bogutska Olexandr Motuziuk Natalia Nurishchenko Yuriy Prylutskyy Peter Scharff Uwe Ritter Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats International Journal of Molecular Sciences C<sub>60</sub> fullerene muscle soleus of rat ischemia biomechanical and biochemical parameters |
author_facet |
Dmytro Nozdrenko Tetiana Matvienko Oksana Vygovska Kateryna Bogutska Olexandr Motuziuk Natalia Nurishchenko Yuriy Prylutskyy Peter Scharff Uwe Ritter |
author_sort |
Dmytro Nozdrenko |
title |
Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats |
title_short |
Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats |
title_full |
Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats |
title_fullStr |
Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats |
title_full_unstemmed |
Protective Effect of Water-Soluble C<sub>60</sub> Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats |
title_sort |
protective effect of water-soluble c<sub>60</sub> fullerene nanoparticles on the ischemia-reperfusion injury of the muscle soleus in rats |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
The biomechanical parameters of muscle soleus contraction in rats and their blood biochemical indicators after the intramuscular administration of water-soluble C<sub>60</sub> fullerene at doses of 0.5, 1, and 2 mg/kg 1 h before the onset of muscle ischemia were investigated. In particular, changes in the contraction force of the ischemic muscle soleus, the integrated power of the muscle, the time to achieve the maximum force response, the dynamics of fatigue processes, and the parameters of the transition from dentate to smooth tetanus, levels of creatinine, creatine kinase, lactate and lactate dehydrogenase, and parameters of prooxidant–antioxidant balance (thiobarbituric acid reactive substances, hydrogen peroxide, and reduced glutathione and catalase) were analyzed. The positive therapeutic changes in the studied biomechanical and biochemical markers were revealed, which indicate the possibility of using water-soluble C<sub>60</sub> fullerenes as effective prophylactic nanoagents to reduce the severity of pathological conditions of the muscular system caused by ischemic damage to skeletal muscles. |
topic |
C<sub>60</sub> fullerene muscle soleus of rat ischemia biomechanical and biochemical parameters |
url |
https://www.mdpi.com/1422-0067/22/13/6812 |
work_keys_str_mv |
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