Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study
Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating cli...
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doaj-1db5758dfe55411b8f2c87237556e2c22020-12-23T00:02:10ZengMDPI AGDentistry Journal2304-67672021-12-0191110.3390/dj9010001Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control StudyFederica Di Spirito0Michele La Rocca1Maddalena De Bernardo2Nicola Rosa3Carolina Sbordone4Ludovico Sbordone5Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, 84081 Baronissi, ItalyDepartment of Economics and Statistics, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, 84081 Baronissi, ItalyDepartment of Radiology, School of Medicine, University of Molise, Via Giovanni Paolo II, Contrada “Tappino”, 86100 Campobasso, ItalyDepartment of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, 84081 Baronissi, ItalyOral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional <i>t</i>-tests and Yuen’s test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders.https://www.mdpi.com/2304-6767/9/1/1ARMDmacular degenerationperiodontitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Di Spirito Michele La Rocca Maddalena De Bernardo Nicola Rosa Carolina Sbordone Ludovico Sbordone |
spellingShingle |
Federica Di Spirito Michele La Rocca Maddalena De Bernardo Nicola Rosa Carolina Sbordone Ludovico Sbordone Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study Dentistry Journal ARMD macular degeneration periodontitis |
author_facet |
Federica Di Spirito Michele La Rocca Maddalena De Bernardo Nicola Rosa Carolina Sbordone Ludovico Sbordone |
author_sort |
Federica Di Spirito |
title |
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study |
title_short |
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study |
title_full |
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study |
title_fullStr |
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study |
title_full_unstemmed |
Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study |
title_sort |
possible association of periodontal disease and macular degeneration: a case-control study |
publisher |
MDPI AG |
series |
Dentistry Journal |
issn |
2304-6767 |
publishDate |
2021-12-01 |
description |
Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional <i>t</i>-tests and Yuen’s test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders. |
topic |
ARMD macular degeneration periodontitis |
url |
https://www.mdpi.com/2304-6767/9/1/1 |
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