Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this re...

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Main Authors:	Evan F. Garner, Elizabeth A. Beierle
Format:	Article
Language:	English
Published:	MDPI AG 2015-12-01
Series:	Cancers
Subjects:	neuroblastoma cancer stem cell cancer-associated fibroblasts hypoxia
Online Access:	http://www.mdpi.com/2072-6694/8/1/5

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spelling	doaj-1dc493f2c36f4f47942e58070b311aec2020-11-24T21:58:33ZengMDPI AGCancers2072-66942015-12-0181510.3390/cancers8010005cancers8010005Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in NeuroblastomaEvan F. Garner0Elizabeth A. Beierle1Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USADepartment of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USANeuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.http://www.mdpi.com/2072-6694/8/1/5neuroblastomacancer stem cellcancer-associated fibroblastshypoxia
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Evan F. Garner Elizabeth A. Beierle
spellingShingle	Evan F. Garner Elizabeth A. Beierle Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma Cancers neuroblastoma cancer stem cell cancer-associated fibroblasts hypoxia
author_facet	Evan F. Garner Elizabeth A. Beierle
author_sort	Evan F. Garner
title	Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_short	Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_full	Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_fullStr	Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_full_unstemmed	Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_sort	cancer stem cells and their interaction with the tumor microenvironment in neuroblastoma
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2015-12-01
description	Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
topic	neuroblastoma cancer stem cell cancer-associated fibroblasts hypoxia
url	http://www.mdpi.com/2072-6694/8/1/5
work_keys_str_mv	AT evanfgarner cancerstemcellsandtheirinteractionwiththetumormicroenvironmentinneuroblastoma AT elizabethabeierle cancerstemcellsandtheirinteractionwiththetumormicroenvironmentinneuroblastoma
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Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

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