Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. The di...

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Bibliographic Details
Main Authors: Anita Carija, Francisca Pinheiro, Jordi Pujols, Inês C. Brás, Diana Fernandes Lázaro, Carlo Santambrogio, Rita Grandori, Tiago F. Outeiro, Susanna Navarro, Salvador Ventura
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718309789

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