The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13198 |
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doaj-1de87b299b0044dc8a38c75fa107c015 |
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doaj-1de87b299b0044dc8a38c75fa107c0152021-05-11T10:48:19ZengNature Publishing GroupNature Communications2041-17232016-10-017111410.1038/ncomms13198The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activationKwok Ho Yip0Natasha Kolesnikoff1Nicholas Hauschild2Lisa Biggs3Angel F. Lopez4Stephen J. Galli5Sharad Kumar6Michele A. Grimbaldeston7Centre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyDepartments of Pathology and of Microbiology and Immunology, and the Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of MedicineCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyAberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.https://doi.org/10.1038/ncomms13198 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston |
| spellingShingle |
Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation Nature Communications |
| author_facet |
Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston |
| author_sort |
Kwok Ho Yip |
| title |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_short |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_full |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_fullStr |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_full_unstemmed |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_sort |
nedd4-2/ndfip1 axis is a negative regulator of ige-mediated mast cell activation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-10-01 |
| description |
Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation. |
| url |
https://doi.org/10.1038/ncomms13198 |
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