The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.

The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.

In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular p...

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Main Authors: Liv-Marie Eike, Brynjar Mauseth, Ketil André Camilio, Øystein Rekdal, Baldur Sveinbjørnsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4755540?pdf=render
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spelling doaj-1defea10541e4d17a3589cd31b8a5dce2020-11-25T01:35:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014898010.1371/journal.pone.0148980The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.Liv-Marie EikeBrynjar MausethKetil André CamilioØystein RekdalBaldur SveinbjørnssonIn the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated cells. The use of a murine melanoma model demonstrated that the majority of animals treated with intratumoural injections of LTX-401 showed complete and long-lasting remission. Taken together, these results demonstrate the potential of LTX-401 as an immunotherapeutic agent for the treatment of solid tumors.http://europepmc.org/articles/PMC4755540?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Liv-Marie Eike
Brynjar Mauseth
Ketil André Camilio
Øystein Rekdal
Baldur Sveinbjørnsson
spellingShingle Liv-Marie Eike
Brynjar Mauseth
Ketil André Camilio
Øystein Rekdal
Baldur Sveinbjørnsson
The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
PLoS ONE
author_facet Liv-Marie Eike
Brynjar Mauseth
Ketil André Camilio
Øystein Rekdal
Baldur Sveinbjørnsson
author_sort Liv-Marie Eike
title The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
title_short The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
title_full The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
title_fullStr The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
title_full_unstemmed The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
title_sort cytolytic amphipathic β(2,2)-amino acid ltx-401 induces damp release in melanoma cells and causes complete regression of b16 melanoma.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated cells. The use of a murine melanoma model demonstrated that the majority of animals treated with intratumoural injections of LTX-401 showed complete and long-lasting remission. Taken together, these results demonstrate the potential of LTX-401 as an immunotherapeutic agent for the treatment of solid tumors.
url http://europepmc.org/articles/PMC4755540?pdf=render
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