BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT

Due to the permanent discordance between the number of available liver grafts and the number of cases on the waiting lists, attention was focused on developing different solutions in order to increase the number of grafts. Once the technique of living donor has been proposed, the number of grafts...

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Main Authors: Nicolae Bacalbasa, Irina Balescu, Adina Croitoru, Simona Dima, Mihaela Vilcu, Iulian Brezean
Format: Article
Language:English
Published: Amaltea Medical Publishing House 2019-09-01
Series:Romanian Medical Journal
Subjects:
Online Access:https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-12.pdf
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spelling doaj-1df0ed10dba64762a6a4afdf66988e302021-09-02T21:17:40ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2019-09-0166323924210.37897/RMJ.2019.3.12BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANTNicolae Bacalbasa0Irina Balescu1Adina Croitoru2Simona Dima3Mihaela Vilcu4Iulian Brezean5“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Ion Cantacuzino” Clinical Hospital, Bucharest, Romania“Ponderas” Academic Hospital, Bucharest, RomaniaFundeni Clinical Institute, Bucharest, Romania; Faculty of Medicine, “Titu Maiorescu” University, Bucharest, RomaniaFundeni Clinical Institute, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Ion Cantacuzino” Clinical Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Ion Cantacuzino” Clinical Hospital, Bucharest, RomaniaDue to the permanent discordance between the number of available liver grafts and the number of cases on the waiting lists, attention was focused on developing different solutions in order to increase the number of grafts. Once the technique of living donor has been proposed, the number of grafts increased but the gap between the number of available grafts and the cases on the waiting list is still significant. Therefore attention was focused on finding out other solutions such as splitting the graft or performing a domino liver transplant. The procedure of domino transplant consists of harvesting a graft from a young patient with metabolic disorders in which a healthy graft will be used and implants it to a marginal receiver. The method seems to associate minimal risks for the marginal donor to develop the metabolic disorder especially if the donor suffers from familial amyloid polyneuropathy; however, ethical issues in such cases are obvious. The aim of this paper is to analyse both the benefits of domino liver transplant and the ethical issues of the procedure.https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-12.pdfdomino liver transplantmetabolic disorderssurvivalethical issues
collection DOAJ
language English
format Article
sources DOAJ
author Nicolae Bacalbasa
Irina Balescu
Adina Croitoru
Simona Dima
Mihaela Vilcu
Iulian Brezean
spellingShingle Nicolae Bacalbasa
Irina Balescu
Adina Croitoru
Simona Dima
Mihaela Vilcu
Iulian Brezean
BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
Romanian Medical Journal
domino liver transplant
metabolic disorders
survival
ethical issues
author_facet Nicolae Bacalbasa
Irina Balescu
Adina Croitoru
Simona Dima
Mihaela Vilcu
Iulian Brezean
author_sort Nicolae Bacalbasa
title BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
title_short BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
title_full BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
title_fullStr BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
title_full_unstemmed BENEFITS AND ETHICAL ISSUES IN DOMINO LIVER TRANSPLANT
title_sort benefits and ethical issues in domino liver transplant
publisher Amaltea Medical Publishing House
series Romanian Medical Journal
issn 1220-5478
2069-606X
publishDate 2019-09-01
description Due to the permanent discordance between the number of available liver grafts and the number of cases on the waiting lists, attention was focused on developing different solutions in order to increase the number of grafts. Once the technique of living donor has been proposed, the number of grafts increased but the gap between the number of available grafts and the cases on the waiting list is still significant. Therefore attention was focused on finding out other solutions such as splitting the graft or performing a domino liver transplant. The procedure of domino transplant consists of harvesting a graft from a young patient with metabolic disorders in which a healthy graft will be used and implants it to a marginal receiver. The method seems to associate minimal risks for the marginal donor to develop the metabolic disorder especially if the donor suffers from familial amyloid polyneuropathy; however, ethical issues in such cases are obvious. The aim of this paper is to analyse both the benefits of domino liver transplant and the ethical issues of the procedure.
topic domino liver transplant
metabolic disorders
survival
ethical issues
url https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-12.pdf
work_keys_str_mv AT nicolaebacalbasa benefitsandethicalissuesindominolivertransplant
AT irinabalescu benefitsandethicalissuesindominolivertransplant
AT adinacroitoru benefitsandethicalissuesindominolivertransplant
AT simonadima benefitsandethicalissuesindominolivertransplant
AT mihaelavilcu benefitsandethicalissuesindominolivertransplant
AT iulianbrezean benefitsandethicalissuesindominolivertransplant
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