Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.

OBJECTIVE: Much controversy still exists about maternal-to-infant transmission of human papillomavirus (HPV) infection, specifically about the magnitude of the risk and the route and timing of such vertical transmission. This prospective cohort study examines the risk of vertical transmission of mat...

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Main Authors: Seung Mi Lee, Joong Shin Park, Errol R Norwitz, Ja Nam Koo, Ig Hwan Oh, Jeong Woo Park, Sun Min Kim, Yun Hwan Kim, Chan-Wook Park, Yong Sang Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3681772?pdf=render
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spelling doaj-1df6e36a92d145d098133dfdc1d5df5d2020-11-25T02:42:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6636810.1371/journal.pone.0066368Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.Seung Mi LeeJoong Shin ParkErrol R NorwitzJa Nam KooIg Hwan OhJeong Woo ParkSun Min KimYun Hwan KimChan-Wook ParkYong Sang SongOBJECTIVE: Much controversy still exists about maternal-to-infant transmission of human papillomavirus (HPV) infection, specifically about the magnitude of the risk and the route and timing of such vertical transmission. This prospective cohort study examines the risk of vertical transmission of maternal HPV in each trimester of pregnancy. STUDY DESIGN: One hundred fifty three healthy pregnant women were followed longitudinally throughout pregnancy and cervical swabs obtained in each trimester and postpartum for HPV detection. Cord blood, neonatal nasopharyngeal aspirates, and placental biopsies were collected at delivery. DNA isolation, polymerase chain reaction, and hybridization were performed using the GG HPV Genotyping Chip Kit (Goodgene Inc., Seoul, Korea). Detection of HPV in neonates was defined as the presence of HPV DNA in either cord blood or neonatal nasopharyngeal aspirate. RESULTS: HPV DNA was detected in 14%(22/153) of healthy women in the first trimester, 18%(22/124) in the second trimester, and 10%(15/153) in the third trimester; 24%(37/153) were positive for HPV DNA on at least one occasion in pregnancy. At birth, 5.2%(8/153) of neonates were HPV DNA positive. Seven of these eight infants were born to HPV-positive mothers. Placental HPV DNA was positive in 3.3%(5/152) of cases, and all five cases were from mothers with at least one HPV-positive test. Detection of HPV DNA in neonates was associated with detection of HPV in mothers during any of the three trimesters of pregnancy. CONCLUSION: HPV DNA was detected at birth in 5.2%(8/153) of neonates born to healthy women, and was associated with the detection of HPV in mothers during any of the three trimesters of pregnancy.http://europepmc.org/articles/PMC3681772?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Seung Mi Lee
Joong Shin Park
Errol R Norwitz
Ja Nam Koo
Ig Hwan Oh
Jeong Woo Park
Sun Min Kim
Yun Hwan Kim
Chan-Wook Park
Yong Sang Song
spellingShingle Seung Mi Lee
Joong Shin Park
Errol R Norwitz
Ja Nam Koo
Ig Hwan Oh
Jeong Woo Park
Sun Min Kim
Yun Hwan Kim
Chan-Wook Park
Yong Sang Song
Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
PLoS ONE
author_facet Seung Mi Lee
Joong Shin Park
Errol R Norwitz
Ja Nam Koo
Ig Hwan Oh
Jeong Woo Park
Sun Min Kim
Yun Hwan Kim
Chan-Wook Park
Yong Sang Song
author_sort Seung Mi Lee
title Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
title_short Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
title_full Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
title_fullStr Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
title_full_unstemmed Risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
title_sort risk of vertical transmission of human papillomavirus throughout pregnancy: a prospective study.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description OBJECTIVE: Much controversy still exists about maternal-to-infant transmission of human papillomavirus (HPV) infection, specifically about the magnitude of the risk and the route and timing of such vertical transmission. This prospective cohort study examines the risk of vertical transmission of maternal HPV in each trimester of pregnancy. STUDY DESIGN: One hundred fifty three healthy pregnant women were followed longitudinally throughout pregnancy and cervical swabs obtained in each trimester and postpartum for HPV detection. Cord blood, neonatal nasopharyngeal aspirates, and placental biopsies were collected at delivery. DNA isolation, polymerase chain reaction, and hybridization were performed using the GG HPV Genotyping Chip Kit (Goodgene Inc., Seoul, Korea). Detection of HPV in neonates was defined as the presence of HPV DNA in either cord blood or neonatal nasopharyngeal aspirate. RESULTS: HPV DNA was detected in 14%(22/153) of healthy women in the first trimester, 18%(22/124) in the second trimester, and 10%(15/153) in the third trimester; 24%(37/153) were positive for HPV DNA on at least one occasion in pregnancy. At birth, 5.2%(8/153) of neonates were HPV DNA positive. Seven of these eight infants were born to HPV-positive mothers. Placental HPV DNA was positive in 3.3%(5/152) of cases, and all five cases were from mothers with at least one HPV-positive test. Detection of HPV DNA in neonates was associated with detection of HPV in mothers during any of the three trimesters of pregnancy. CONCLUSION: HPV DNA was detected at birth in 5.2%(8/153) of neonates born to healthy women, and was associated with the detection of HPV in mothers during any of the three trimesters of pregnancy.
url http://europepmc.org/articles/PMC3681772?pdf=render
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