Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report
There is a known relationship between Clostridium septicum bacteremia and colorectal malignancies. C. septicum is a gram-positive, anaerobic, spore-forming bacterium that can survive the acidic colorectal tumor microenvironment, where it is thought to enter the blood by tumor-mediated epithelial tis...
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2021-01-01
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doaj-1e018cffdb934e3e8ac10e497d3d2d862021-09-11T04:29:07ZengElsevierIDCases2214-25092021-01-0125e01189Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case ReportDavid Chirikian0Sohun Awsare1John Fitzgibbon2Lenora Lee3California Northstate University College of Medicine, 9700 West Taron Drive, Elk Grove, CA, 95757, USA; Corresponding author.California Northstate University College of Medicine, 9700 West Taron Drive, Elk Grove, CA, 95757, USACalifornia Northstate University College of Medicine, 9700 West Taron Drive, Elk Grove, CA, 95757, USADepartment of Infectious Disease, Kaiser Permanente Sacramento Medical Center, 2025 Morse Avenue, Sacramento, CA, 95825, USAThere is a known relationship between Clostridium septicum bacteremia and colorectal malignancies. C. septicum is a gram-positive, anaerobic, spore-forming bacterium that can survive the acidic colorectal tumor microenvironment, where it is thought to enter the blood by tumor-mediated epithelial tissue damage. While in circulation, C. septicum can release exotoxins which may lead to life-threatening sepsis. The patient in this case presented with a mild fever, abdominal pain, and left hand weakness. Imaging of the head and abdomen revealed a right frontal lucency and wall thickening of the ascending colon. Two colonic adenocarcinomas were found and removed via an exploratory laparotomy and right hemicolectomy. The blood culture was positive for C. septicum. Brain MRI confirmed a right frontal mass concerning for metastasis. Here, we discuss the relationship between colonic cancers and Clostridium septicum bacteremia.http://www.sciencedirect.com/science/article/pii/S2214250921001451Colorectal malignancyBacteremiaBrain metastasisAdenocarcinomaClostridium septicum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Chirikian Sohun Awsare John Fitzgibbon Lenora Lee |
spellingShingle |
David Chirikian Sohun Awsare John Fitzgibbon Lenora Lee Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report IDCases Colorectal malignancy Bacteremia Brain metastasis Adenocarcinoma Clostridium septicum |
author_facet |
David Chirikian Sohun Awsare John Fitzgibbon Lenora Lee |
author_sort |
David Chirikian |
title |
Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report |
title_short |
Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report |
title_full |
Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report |
title_fullStr |
Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report |
title_full_unstemmed |
Concurrent Clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – A Case Report |
title_sort |
concurrent clostridium septicum bacteremia and colorectal adenocarcinoma with metastasis to the brain – a case report |
publisher |
Elsevier |
series |
IDCases |
issn |
2214-2509 |
publishDate |
2021-01-01 |
description |
There is a known relationship between Clostridium septicum bacteremia and colorectal malignancies. C. septicum is a gram-positive, anaerobic, spore-forming bacterium that can survive the acidic colorectal tumor microenvironment, where it is thought to enter the blood by tumor-mediated epithelial tissue damage. While in circulation, C. septicum can release exotoxins which may lead to life-threatening sepsis. The patient in this case presented with a mild fever, abdominal pain, and left hand weakness. Imaging of the head and abdomen revealed a right frontal lucency and wall thickening of the ascending colon. Two colonic adenocarcinomas were found and removed via an exploratory laparotomy and right hemicolectomy. The blood culture was positive for C. septicum. Brain MRI confirmed a right frontal mass concerning for metastasis. Here, we discuss the relationship between colonic cancers and Clostridium septicum bacteremia. |
topic |
Colorectal malignancy Bacteremia Brain metastasis Adenocarcinoma Clostridium septicum |
url |
http://www.sciencedirect.com/science/article/pii/S2214250921001451 |
work_keys_str_mv |
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