Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules
To explore the association between 18F-FDG PET/CT-based SUV index and malignant risk of persistent ground-glass nodules (GGNs). We retrospectively analyzed a total of 166 patients with GGN who underwent PET/CT examination from January 2012 to October 2019. There were 113 women and 53 men, with an av...
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doaj-1e07dcf64ad04116b5398b5eb63119602021-03-24T06:13:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.594693594693Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass NodulesRong Niu0Rong Niu1Yuetao Wang2Yuetao Wang3Xiaoliang Shao4Xiaoliang Shao5Zhenxing Jiang6Jianfeng Wang7Jianfeng Wang8Xiaonan Shao9Xiaonan Shao10Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaChangzhou Key Laboratory of Molecular Imaging, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaChangzhou Key Laboratory of Molecular Imaging, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaChangzhou Key Laboratory of Molecular Imaging, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaChangzhou Key Laboratory of Molecular Imaging, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaChangzhou Key Laboratory of Molecular Imaging, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaTo explore the association between 18F-FDG PET/CT-based SUV index and malignant risk of persistent ground-glass nodules (GGNs). We retrospectively analyzed a total of 166 patients with GGN who underwent PET/CT examination from January 2012 to October 2019. There were 113 women and 53 men, with an average age of 60.8 ± 9.1 years old. A total of 192 GGNs were resected and confirmed by pathology, including 22 in benign group and 170 in adenocarcinoma group. They were divided into three groups according to SUV index tertiles: Tertile 1 (0.14–0.54), Tertile 2 (0.55–1.17), and Tertile 3 (1.19–6.78), with 64 GGNs in each group. The clinical and imaging data of all patients were collected and analyzed. After adjusting for the potential confounding factors, we found that the malignancy risk of GGN significantly decreased as the SUV index increased (OR, 0.245; 95%CI, 0.119–0.504; P <0.001), the average probability of malignant GGN was 89.1% (95% CI, 53.1–98.3%), 80.5% (95% CI, 36.7–96.7%), and 34.3% (95%CI, 9.5–72.2%) for Tertile 1 to Tertile 3. And the increasing trend of SUV index was significantly correlated with the reduction of malignant risk (OR, 0.099; 95%CI, 0.025–0.394; P = 0.001), especially between Tertile 3 versus Tertile 1 (OR, 0.064; 95%CI, 0.012–0.356; P = 0.002). Curve fitting showed that the SUV index was linearly and negatively correlated with the malignant risk of GGN. SUV index is an independent correlation factor for malignancy risk of GGN, the higher the SUV index, the lower the probability of GGN malignancy.https://www.frontiersin.org/articles/10.3389/fonc.2021.594693/fulladenocarcinoma of lungrisk factorspositron emission tomography computed tomographyfluorodeoxyglucose F18ground-glass nodule |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rong Niu Rong Niu Yuetao Wang Yuetao Wang Xiaoliang Shao Xiaoliang Shao Zhenxing Jiang Jianfeng Wang Jianfeng Wang Xiaonan Shao Xiaonan Shao |
spellingShingle |
Rong Niu Rong Niu Yuetao Wang Yuetao Wang Xiaoliang Shao Xiaoliang Shao Zhenxing Jiang Jianfeng Wang Jianfeng Wang Xiaonan Shao Xiaonan Shao Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules Frontiers in Oncology adenocarcinoma of lung risk factors positron emission tomography computed tomography fluorodeoxyglucose F18 ground-glass nodule |
author_facet |
Rong Niu Rong Niu Yuetao Wang Yuetao Wang Xiaoliang Shao Xiaoliang Shao Zhenxing Jiang Jianfeng Wang Jianfeng Wang Xiaonan Shao Xiaonan Shao |
author_sort |
Rong Niu |
title |
Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules |
title_short |
Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules |
title_full |
Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules |
title_fullStr |
Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules |
title_full_unstemmed |
Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules |
title_sort |
association between 18f-fdg pet/ct-based suv index and malignant status of persistent ground-glass nodules |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-03-01 |
description |
To explore the association between 18F-FDG PET/CT-based SUV index and malignant risk of persistent ground-glass nodules (GGNs). We retrospectively analyzed a total of 166 patients with GGN who underwent PET/CT examination from January 2012 to October 2019. There were 113 women and 53 men, with an average age of 60.8 ± 9.1 years old. A total of 192 GGNs were resected and confirmed by pathology, including 22 in benign group and 170 in adenocarcinoma group. They were divided into three groups according to SUV index tertiles: Tertile 1 (0.14–0.54), Tertile 2 (0.55–1.17), and Tertile 3 (1.19–6.78), with 64 GGNs in each group. The clinical and imaging data of all patients were collected and analyzed. After adjusting for the potential confounding factors, we found that the malignancy risk of GGN significantly decreased as the SUV index increased (OR, 0.245; 95%CI, 0.119–0.504; P <0.001), the average probability of malignant GGN was 89.1% (95% CI, 53.1–98.3%), 80.5% (95% CI, 36.7–96.7%), and 34.3% (95%CI, 9.5–72.2%) for Tertile 1 to Tertile 3. And the increasing trend of SUV index was significantly correlated with the reduction of malignant risk (OR, 0.099; 95%CI, 0.025–0.394; P = 0.001), especially between Tertile 3 versus Tertile 1 (OR, 0.064; 95%CI, 0.012–0.356; P = 0.002). Curve fitting showed that the SUV index was linearly and negatively correlated with the malignant risk of GGN. SUV index is an independent correlation factor for malignancy risk of GGN, the higher the SUV index, the lower the probability of GGN malignancy. |
topic |
adenocarcinoma of lung risk factors positron emission tomography computed tomography fluorodeoxyglucose F18 ground-glass nodule |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.594693/full |
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