Malignant Melanoma
Melanomas are a major cause of premature death from cancer. The gradual decrease in rates of morbidity and mortality has occurred as a result of public health campaigns and improved rates of early diagnosis. Survival of melanoma has increased to over 90%. Management of melanoma involves a number of...
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doaj-1e096cfd6b854687a072e7b9297bec962020-11-24T21:40:06ZengMDPI AGHealthcare2227-90322013-12-012111910.3390/healthcare2010001healthcare2010001Malignant MelanomaEshini Perera0Neiraja Gnaneswaran1Ross Jennens2Rodney Sinclair3Faculty of Medicine, Dentistry and Health Sciences, Melbourne University, Victoria 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, Melbourne University, Victoria 3010, AustraliaEpworth Healthcare, 32 Erin St, Richmond, Victoria 3121, AustraliaEpworth Dermatology, Suite 5.1, 32 Erin St, Richmond, Victoria 3121, AustraliaMelanomas are a major cause of premature death from cancer. The gradual decrease in rates of morbidity and mortality has occurred as a result of public health campaigns and improved rates of early diagnosis. Survival of melanoma has increased to over 90%. Management of melanoma involves a number of components: excision, tumor staging, re-excision with negative margins, adjuvant therapies (chemo, radiation or surgery), treatment of stage IV disease, follow-up examination for metastasis, lifestyle modification and counseling. Sentinel lymph node status is an important prognostic factor for survival in patients with a melanoma >1 mm. However, sentinel lymph node biopsies have received partial support due to the limited data regarding the survival advantage of complete lymph node dissection when a micrometastasis is detected in the lymph nodes. Functional mutations in the mitogen-activated pathways are commonly detected in melanomas and these influence the growth control. Therapies that target these pathways are rapidly emerging, and are being shown to increase survival rates in patients. Access to these newer agents can be gained by participation in clinical trials after referral to a multidisciplinary team for staging and re-excision of the scar.http://www.mdpi.com/2227-9032/2/1/1melanomamelanocytemelaninnevusskin cancermalignant melanomanodular melanomamolescancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eshini Perera Neiraja Gnaneswaran Ross Jennens Rodney Sinclair |
spellingShingle |
Eshini Perera Neiraja Gnaneswaran Ross Jennens Rodney Sinclair Malignant Melanoma Healthcare melanoma melanocyte melanin nevus skin cancer malignant melanoma nodular melanoma moles cancer |
author_facet |
Eshini Perera Neiraja Gnaneswaran Ross Jennens Rodney Sinclair |
author_sort |
Eshini Perera |
title |
Malignant Melanoma |
title_short |
Malignant Melanoma |
title_full |
Malignant Melanoma |
title_fullStr |
Malignant Melanoma |
title_full_unstemmed |
Malignant Melanoma |
title_sort |
malignant melanoma |
publisher |
MDPI AG |
series |
Healthcare |
issn |
2227-9032 |
publishDate |
2013-12-01 |
description |
Melanomas are a major cause of premature death from cancer. The gradual decrease in rates of morbidity and mortality has occurred as a result of public health campaigns and improved rates of early diagnosis. Survival of melanoma has increased to over 90%. Management of melanoma involves a number of components: excision, tumor staging, re-excision with negative margins, adjuvant therapies (chemo, radiation or surgery), treatment of stage IV disease, follow-up examination for metastasis, lifestyle modification and counseling. Sentinel lymph node status is an important prognostic factor for survival in patients with a melanoma >1 mm. However, sentinel lymph node biopsies have received partial support due to the limited data regarding the survival advantage of complete lymph node dissection when a micrometastasis is detected in the lymph nodes. Functional mutations in the mitogen-activated pathways are commonly detected in melanomas and these influence the growth control. Therapies that target these pathways are rapidly emerging, and are being shown to increase survival rates in patients. Access to these newer agents can be gained by participation in clinical trials after referral to a multidisciplinary team for staging and re-excision of the scar. |
topic |
melanoma melanocyte melanin nevus skin cancer malignant melanoma nodular melanoma moles cancer |
url |
http://www.mdpi.com/2227-9032/2/1/1 |
work_keys_str_mv |
AT eshiniperera malignantmelanoma AT neirajagnaneswaran malignantmelanoma AT rossjennens malignantmelanoma AT rodneysinclair malignantmelanoma |
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