Alzheimer's brains show inter-related changes in RNA and lipid metabolism

Alzheimer's brains show inter-related changes in RNA and lipid metabolism

Alzheimer's disease (AD) involves changes in both lipid and RNA metabolism, but it remained unknown if these differences associate with AD's cognition and/or post-mortem neuropathology indices. Here, we report RNA-sequencing evidence of inter-related associations between lipid processing,...

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Bibliographic Details
Main Authors: Shahar Barbash, Benjamin P. Garfinkel, Rotem Maoz, Alon Simchovitz, Bettina Nadorp, Alessandro Guffanti, Estelle R. Bennett, Courtney Nadeau, Andreas Türk, Lukas Paul, Torsten Reda, Yan Li, Aron S. Buchman, David S. Greenberg, Alexander Seitz, David A. Bennett, Patrick Giavalisco, Hermona Soreq
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Alternative polyadenylation
Lipidomics
RNA sequencing
Cognitive decline
Neuropathology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301353

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