Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1−3) along with a trinorditerpene, enbepeanone A (4...

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Main Authors:	Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Marine Drugs
Subjects:	briarane diterpene cytotoxicity screening deep sea pennatulacea marine natural products
Online Access:	https://www.mdpi.com/1660-3397/17/9/513

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spelling	doaj-1e0cf715bf5e474095001ad96870103e2020-11-25T01:20:32ZengMDPI AGMarine Drugs1660-33972019-09-0117951310.3390/md17090513md17090513Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)Santana A.L. Thomas0Anthony Sanchez1Younghoon Kee2Nerida G. Wilson3Bill J. Baker4Department of Chemistry, University of South Florida, Tampa, FL 33620, USADepartment of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USAWestern Australia Museum and the University of Western Australia, Perth, WA 6106, AustraliaDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USAAn Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (<b>1</b>−<b>3</b>) along with a trinorditerpene, enbepeanone A (<b>4</b>), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.https://www.mdpi.com/1660-3397/17/9/513briarane diterpenecytotoxicity screeningdeep seapennatulaceamarine natural products
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker
spellingShingle	Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) Marine Drugs briarane diterpene cytotoxicity screening deep sea pennatulacea marine natural products
author_facet	Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker
author_sort	Santana A.L. Thomas
title	Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
title_short	Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
title_full	Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
title_fullStr	Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
title_full_unstemmed	Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
title_sort	bathyptilones: terpenoids from an antarctic sea pen, <i>anthoptilum grandiflorum</i> (verrill, 1879)
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2019-09-01
description	An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (<b>1</b>−<b>3</b>) along with a trinorditerpene, enbepeanone A (<b>4</b>), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.
topic	briarane diterpene cytotoxicity screening deep sea pennatulacea marine natural products
url	https://www.mdpi.com/1660-3397/17/9/513
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Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)

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