Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)
An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (<b>1</b>−<b>3</b>) along with a trinorditerpene, enbepeanone A (<b>4...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-09-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/17/9/513 |
id |
doaj-1e0cf715bf5e474095001ad96870103e |
---|---|
record_format |
Article |
spelling |
doaj-1e0cf715bf5e474095001ad96870103e2020-11-25T01:20:32ZengMDPI AGMarine Drugs1660-33972019-09-0117951310.3390/md17090513md17090513Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)Santana A.L. Thomas0Anthony Sanchez1Younghoon Kee2Nerida G. Wilson3Bill J. Baker4Department of Chemistry, University of South Florida, Tampa, FL 33620, USADepartment of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USADepartment of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USAWestern Australia Museum and the University of Western Australia, Perth, WA 6106, AustraliaDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USAAn Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (<b>1</b>−<b>3</b>) along with a trinorditerpene, enbepeanone A (<b>4</b>), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.https://www.mdpi.com/1660-3397/17/9/513briarane diterpenecytotoxicity screeningdeep seapennatulaceamarine natural products |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker |
spellingShingle |
Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) Marine Drugs briarane diterpene cytotoxicity screening deep sea pennatulacea marine natural products |
author_facet |
Santana A.L. Thomas Anthony Sanchez Younghoon Kee Nerida G. Wilson Bill J. Baker |
author_sort |
Santana A.L. Thomas |
title |
Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) |
title_short |
Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) |
title_full |
Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) |
title_fullStr |
Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) |
title_full_unstemmed |
Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879) |
title_sort |
bathyptilones: terpenoids from an antarctic sea pen, <i>anthoptilum grandiflorum</i> (verrill, 1879) |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2019-09-01 |
description |
An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (<b>1</b>−<b>3</b>) along with a trinorditerpene, enbepeanone A (<b>4</b>), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2. |
topic |
briarane diterpene cytotoxicity screening deep sea pennatulacea marine natural products |
url |
https://www.mdpi.com/1660-3397/17/9/513 |
work_keys_str_mv |
AT santanaalthomas bathyptilonesterpenoidsfromanantarcticseapenianthoptilumgrandiflorumiverrill1879 AT anthonysanchez bathyptilonesterpenoidsfromanantarcticseapenianthoptilumgrandiflorumiverrill1879 AT younghoonkee bathyptilonesterpenoidsfromanantarcticseapenianthoptilumgrandiflorumiverrill1879 AT neridagwilson bathyptilonesterpenoidsfromanantarcticseapenianthoptilumgrandiflorumiverrill1879 AT billjbaker bathyptilonesterpenoidsfromanantarcticseapenianthoptilumgrandiflorumiverrill1879 |
_version_ |
1725133755343962112 |