Photodynamic Therapy for Cancer: Principles

Photodynamic Therapy for Cancer: Principles

The principles of photodynamic therapy (PDT), using drugs (photosensitizers) that are activated by light to become cytotoxic, provide the basis for understanding the current and potential future clinical applications in gastroenterology, general oncology and other specialities. The properties of pho...

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Main Author: Brian C Wilson
Format: Article
Language:English
Published: Hindawi Limited 2002-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2002/743109
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spelling doaj-1e1049475b1b4db5bad6e2bce5d38f642020-11-24T21:05:55ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002002-01-0116639339610.1155/2002/743109Photodynamic Therapy for Cancer: PrinciplesBrian C Wilson0Department of Medical Biophysics, Ontario Cancer Institute/University of Toronto, Toronto, Ontario, CanadaThe principles of photodynamic therapy (PDT), using drugs (photosensitizers) that are activated by light to become cytotoxic, provide the basis for understanding the current and potential future clinical applications in gastroenterology, general oncology and other specialities. The properties of photosensitizers are key to their biological efficacy, while lasers and optical fibres allow convenient and flexible light delivery for endoscopic use. PDT has several distinct and unique advantages, both as a stand-alone treatment and in combination with other established modalities. The current limitations are also recognized, as is the need for rigorous randomized trials of this emerging technology. The fluorescence of many photosensitizers may be useful, either for (endoscopic) diagnosis or for PDT treatment guidance and monitoring.http://dx.doi.org/10.1155/2002/743109
collection DOAJ
language English
format Article
sources DOAJ
author Brian C Wilson
spellingShingle Brian C Wilson
Photodynamic Therapy for Cancer: Principles
Canadian Journal of Gastroenterology
author_facet Brian C Wilson
author_sort Brian C Wilson
title Photodynamic Therapy for Cancer: Principles
title_short Photodynamic Therapy for Cancer: Principles
title_full Photodynamic Therapy for Cancer: Principles
title_fullStr Photodynamic Therapy for Cancer: Principles
title_full_unstemmed Photodynamic Therapy for Cancer: Principles
title_sort photodynamic therapy for cancer: principles
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2002-01-01
description The principles of photodynamic therapy (PDT), using drugs (photosensitizers) that are activated by light to become cytotoxic, provide the basis for understanding the current and potential future clinical applications in gastroenterology, general oncology and other specialities. The properties of photosensitizers are key to their biological efficacy, while lasers and optical fibres allow convenient and flexible light delivery for endoscopic use. PDT has several distinct and unique advantages, both as a stand-alone treatment and in combination with other established modalities. The current limitations are also recognized, as is the need for rigorous randomized trials of this emerging technology. The fluorescence of many photosensitizers may be useful, either for (endoscopic) diagnosis or for PDT treatment guidance and monitoring.
url http://dx.doi.org/10.1155/2002/743109
work_keys_str_mv AT briancwilson photodynamictherapyforcancerprinciples
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