Neuroimaging of Sleep Disturbances in Movement Disorders
Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that oft...
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doaj-1e13506efadf4d1894b03794e192d9bf2020-11-25T02:27:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-09-01910.3389/fneur.2018.00767335709Neuroimaging of Sleep Disturbances in Movement DisordersTayyabah YousafGennaro PaganoHeather WilsonMarios PolitisSleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD). We also explore the current concepts on the neurobiological underpinnings of sleep disorders, including the role of dopaminergic and non-dopaminergic pathways, by evaluating the molecular, structural and functional neuroimaging evidence based on several novel techniques including magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Based on the current state of research, we suggest that neuroimaging is an invaluable tool for assessing structural and functional correlates of sleep disturbances, harboring the ability to shed light on the sleep problems attached to the limited treatment options available today. As our understanding of the pathophysiology of sleep and wake disruption heightens, novel therapeutic approaches are certain to transpire.https://www.frontiersin.org/article/10.3389/fneur.2018.00767/fullneuroimagingmagnetic resonance imagingpositron emission tomographysleepParkinson's diseaseatypical Parkinsonism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tayyabah Yousaf Gennaro Pagano Heather Wilson Marios Politis |
spellingShingle |
Tayyabah Yousaf Gennaro Pagano Heather Wilson Marios Politis Neuroimaging of Sleep Disturbances in Movement Disorders Frontiers in Neurology neuroimaging magnetic resonance imaging positron emission tomography sleep Parkinson's disease atypical Parkinsonism |
author_facet |
Tayyabah Yousaf Gennaro Pagano Heather Wilson Marios Politis |
author_sort |
Tayyabah Yousaf |
title |
Neuroimaging of Sleep Disturbances in Movement Disorders |
title_short |
Neuroimaging of Sleep Disturbances in Movement Disorders |
title_full |
Neuroimaging of Sleep Disturbances in Movement Disorders |
title_fullStr |
Neuroimaging of Sleep Disturbances in Movement Disorders |
title_full_unstemmed |
Neuroimaging of Sleep Disturbances in Movement Disorders |
title_sort |
neuroimaging of sleep disturbances in movement disorders |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-09-01 |
description |
Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD). We also explore the current concepts on the neurobiological underpinnings of sleep disorders, including the role of dopaminergic and non-dopaminergic pathways, by evaluating the molecular, structural and functional neuroimaging evidence based on several novel techniques including magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Based on the current state of research, we suggest that neuroimaging is an invaluable tool for assessing structural and functional correlates of sleep disturbances, harboring the ability to shed light on the sleep problems attached to the limited treatment options available today. As our understanding of the pathophysiology of sleep and wake disruption heightens, novel therapeutic approaches are certain to transpire. |
topic |
neuroimaging magnetic resonance imaging positron emission tomography sleep Parkinson's disease atypical Parkinsonism |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.00767/full |
work_keys_str_mv |
AT tayyabahyousaf neuroimagingofsleepdisturbancesinmovementdisorders AT gennaropagano neuroimagingofsleepdisturbancesinmovementdisorders AT heatherwilson neuroimagingofsleepdisturbancesinmovementdisorders AT mariospolitis neuroimagingofsleepdisturbancesinmovementdisorders |
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