Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.
Bibliographic Details
Main Authors: |
Sihan Li,
Andrew Mecca,
Jeewoo Kim,
Giusy A. Caprara,
Elizabeth L. Wagner,
Ting-Ting Du,
Leonid Petrov,
Wenhao Xu,
Runjia Cui,
Ivan T. Rebustini,
Bechara Kachar,
Anthony W. Peng,
Jung-Bum Shin |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2020-04-01
|
Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-15936-z
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