Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.

Bibliographic Details
Main Authors:	Sihan Li, Andrew Mecca, Jeewoo Kim, Giusy A. Caprara, Elizabeth L. Wagner, Ting-Ting Du, Leonid Petrov, Wenhao Xu, Runjia Cui, Ivan T. Rebustini, Bechara Kachar, Anthony W. Peng, Jung-Bum Shin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15936-z

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spelling	doaj-1e1c4ebb707d4e36929a5c7886e6304d2021-05-11T09:17:36ZengNature Publishing GroupNature Communications2041-17232020-04-0111111510.1038/s41467-020-15936-zMyosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complexSihan Li0Andrew Mecca1Jeewoo Kim2Giusy A. Caprara3Elizabeth L. Wagner4Ting-Ting Du5Leonid Petrov6Wenhao Xu7Runjia Cui8Ivan T. Rebustini9Bechara Kachar10Anthony W. Peng11Jung-Bum Shin12Department of Neuroscience, University of VirginiaDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical CampusDepartment of Neuroscience, University of VirginiaDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical CampusDepartment of Neuroscience, University of VirginiaDepartment of Neuroscience, University of VirginiaDepartment of Mathematics, University of VirginiaGenetically Engineered Murine Model (GEMM) Core, University of VirginiaNational Institute for Deafness and Communications Disorders, National Institute of HealthNational Institute for Deafness and Communications Disorders, National Institute of HealthNational Institute for Deafness and Communications Disorders, National Institute of HealthDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical CampusDepartment of Neuroscience, University of VirginiaHow the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.https://doi.org/10.1038/s41467-020-15936-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin
spellingShingle	Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex Nature Communications
author_facet	Sihan Li Andrew Mecca Jeewoo Kim Giusy A. Caprara Elizabeth L. Wagner Ting-Ting Du Leonid Petrov Wenhao Xu Runjia Cui Ivan T. Rebustini Bechara Kachar Anthony W. Peng Jung-Bum Shin
author_sort	Sihan Li
title	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_short	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_full	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_fullStr	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_full_unstemmed	Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
title_sort	myosin-viia is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.
url	https://doi.org/10.1038/s41467-020-15936-z
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Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

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