Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes f...
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2020-08-01
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Online Access: | https://doi.org/10.1038/s41467-020-17915-w |
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doaj-1e1c9269b742425ab2397a10869c4faa2021-08-15T11:42:00ZengNature Publishing GroupNature Communications2041-17232020-08-0111111510.1038/s41467-020-17915-wScavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− miceHuan Tao0Jiansheng Huang1Patricia G. Yancey2Valery Yermalitsky3John L. Blakemore4Youmin Zhang5Lei Ding6Irene Zagol-Ikapitte7Fei Ye8Venkataraman Amarnath9Olivier Boutaud10John A. Oates11L. Jackson Roberts12Sean S. Davies13MacRae F. Linton14Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of MedicineDepartment of Biostatistics, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineHypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.https://doi.org/10.1038/s41467-020-17915-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton |
spellingShingle |
Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice Nature Communications |
author_facet |
Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton |
author_sort |
Huan Tao |
title |
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice |
title_short |
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice |
title_full |
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice |
title_fullStr |
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice |
title_full_unstemmed |
Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice |
title_sort |
scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic ldlr −/− mice |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-08-01 |
description |
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia. |
url |
https://doi.org/10.1038/s41467-020-17915-w |
work_keys_str_mv |
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