Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice

Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes f...

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Main Authors:	Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17915-w

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spelling	doaj-1e1c9269b742425ab2397a10869c4faa2021-08-15T11:42:00ZengNature Publishing GroupNature Communications2041-17232020-08-0111111510.1038/s41467-020-17915-wScavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− miceHuan Tao0Jiansheng Huang1Patricia G. Yancey2Valery Yermalitsky3John L. Blakemore4Youmin Zhang5Lei Ding6Irene Zagol-Ikapitte7Fei Ye8Venkataraman Amarnath9Olivier Boutaud10John A. Oates11L. Jackson Roberts12Sean S. Davies13MacRae F. Linton14Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of MedicineDepartment of Biostatistics, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Pharmacology, Vanderbilt University School of MedicineDepartment of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University School of MedicineHypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.https://doi.org/10.1038/s41467-020-17915-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton
spellingShingle	Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice Nature Communications
author_facet	Huan Tao Jiansheng Huang Patricia G. Yancey Valery Yermalitsky John L. Blakemore Youmin Zhang Lei Ding Irene Zagol-Ikapitte Fei Ye Venkataraman Amarnath Olivier Boutaud John A. Oates L. Jackson Roberts Sean S. Davies MacRae F. Linton
author_sort	Huan Tao
title	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_short	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_full	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_fullStr	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_full_unstemmed	Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice
title_sort	scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic ldlr −/− mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.
url	https://doi.org/10.1038/s41467-020-17915-w
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Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr −/− mice

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