Role of Biochemical Inflammatory Markers in Patients with Chemotherapy-Induced Neutropenia

• Main Authors: YuN Dubinina, VO Sarzhevskii, VYa Melnichenko
• Format: Article
• Language: Russian
• Published: Practical Medicine Publishing House 2019-09-01
• Series: Kliničeskaâ onkogematologiâ
• Subjects: sepsis; autologous bone marrow transplantation; allogeneic bone marrow transplantation; chemotherapy; infection; procalcitonin; presepsin; c-reactive protein
• Online Access: http://bloodjournal.ru/wp-content/uploads/2019/09/12-1.pdf

The growing number of autologous and allogeneic transplantations of bone marrow and hematopoietic stem cells as well as their technological effectiveness give rise to drug antineoplastic therapies with increased toxicity leading to development of complications. The most serious among this sort of complications are infections. Probability of infections in patients with chemotherapy-induced neutropenia reaches 90 %. In this context the search for an optimal marker of infectious complications becomes more and more important. The present review deals with basic biochemical inflammatory markers and the analysis of trials assessing diagnostic and prognostic value of C-reactive protein, procalcitonin, and presepsin.