Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and polydextrose (PD) were...

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Bibliographic Details
Main Authors: Urve Paaver, Jyrki Heinämäki, Ivan Kassamakov, Tuomo Ylitalo, Edward Hæggström, Ivo Laidmäe, Karin Kogermann
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
wetting
in situ drug release
nanofibers
electrospinning
poorly water-soluble drug
piroxicam
hydroxypropyl methyl cellulose
polydextrose
scanning white light interferometry
Online Access:https://www.mdpi.com/1999-4923/11/10/491

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