Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome
Objectives: High cystatin C(CysC) levels are associated with impaired cardiovascular outcome. Whether CysC levels are independently related to the atherosclerosis burden is still controversial. Methods: We enrolled 31 non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous...
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MDPI AG
2019-02-01
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Online Access: | https://www.mdpi.com/2076-3417/9/4/657 |
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doaj-1e26c627e2264f53a2d034da2eac87e7 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nevio Taglieri Cristina Nanni Gabriele Ghetti Rachele Bonfiglioli Francesco Saia Francesco Buia Giacomo Maria Lima Valeria Marco Antonio Giulio Bruno Francesco Prati Stefano Fanti Claudio Rapezzi |
spellingShingle |
Nevio Taglieri Cristina Nanni Gabriele Ghetti Rachele Bonfiglioli Francesco Saia Francesco Buia Giacomo Maria Lima Valeria Marco Antonio Giulio Bruno Francesco Prati Stefano Fanti Claudio Rapezzi Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome Applied Sciences cystatin C <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography frequency domain-optical coherence tomography coronary artery calcium score non-ST-segment elevation acute coronary syndrome |
author_facet |
Nevio Taglieri Cristina Nanni Gabriele Ghetti Rachele Bonfiglioli Francesco Saia Francesco Buia Giacomo Maria Lima Valeria Marco Antonio Giulio Bruno Francesco Prati Stefano Fanti Claudio Rapezzi |
author_sort |
Nevio Taglieri |
title |
Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome |
title_short |
Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome |
title_full |
Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome |
title_fullStr |
Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome |
title_full_unstemmed |
Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary Syndrome |
title_sort |
multi-imaging investigation to evaluate the relationship between serum cystatin c and features of atherosclerosis in non-st-segment elevation acute coronary syndrome |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2019-02-01 |
description |
Objectives: High cystatin C(CysC) levels are associated with impaired cardiovascular outcome. Whether CysC levels are independently related to the atherosclerosis burden is still controversial. Methods: We enrolled 31 non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. Patients were divided into 2 groups on the basis of median value of serum CysC. Using the high CysC group as a dependent variable, univariable and multivariable analyses were used to evaluate the association between CysC and three different features of atherosclerosis: 1) coronary plaque vulnerability as assessed by optical coherence tomography (OCT), 2) coronary artery calcium (CAC) by means of computed tomography scan, and 3) aortic wall metabolic activity, as assessed using <sup>18</sup>F-Fluorodeoxyglucose-positron emission tomography (<sup>18</sup>F-FDG-PET). Results: After univariable and multivariable analyses, <sup>18</sup>F-FDG uptake in the descending aorta (DA) was independently associated with a low level of CysC [(Odds Ratio = 0.02; 95%CI 0.0004⁻0.89; p = 0.044; <sup>18</sup>F-FDG uptake measured as averaged maximum target to blood ratio); (Odds Ratio = 0.89; 95%CI 0.82⁻0.98, p = 0.025; <sup>18</sup>F-FDG uptake measured as number of active slices)]. No trend was found for the association between CysC and characteristics of OCT-assessed coronary plaque vulnerability or CAC score. Conclusions: In patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), <sup>18</sup>F-FDG uptake in the DA was associated with a low level of serum CysC. There was no relation between CysC levels and OCT-assessed coronary plaque vulnerability or CAC score. These findings suggest that high levels of CysC may not be considered as independent markers of atherosclerosis. |
topic |
cystatin C <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography frequency domain-optical coherence tomography coronary artery calcium score non-ST-segment elevation acute coronary syndrome |
url |
https://www.mdpi.com/2076-3417/9/4/657 |
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doaj-1e26c627e2264f53a2d034da2eac87e72020-11-25T02:11:08ZengMDPI AGApplied Sciences2076-34172019-02-019465710.3390/app9040657app9040657Multi-Imaging Investigation to Evaluate the Relationship between Serum Cystatin C and Features of Atherosclerosis in Non-ST-Segment Elevation Acute Coronary SyndromeNevio Taglieri0Cristina Nanni1Gabriele Ghetti2Rachele Bonfiglioli3Francesco Saia4Francesco Buia5Giacomo Maria Lima6Valeria Marco7Antonio Giulio Bruno8Francesco Prati9Stefano Fanti10Claudio Rapezzi11Polo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyIstituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyPolo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyIstituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyPolo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyIstituto di Radiologia, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyIstituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyCLI Foundation, 00182 Rome, ItalyPolo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyCLI Foundation, 00182 Rome, ItalyIstituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyPolo Cardio-Toraco-Vascolare, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, 40138 Bologna, ItalyObjectives: High cystatin C(CysC) levels are associated with impaired cardiovascular outcome. Whether CysC levels are independently related to the atherosclerosis burden is still controversial. Methods: We enrolled 31 non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. Patients were divided into 2 groups on the basis of median value of serum CysC. Using the high CysC group as a dependent variable, univariable and multivariable analyses were used to evaluate the association between CysC and three different features of atherosclerosis: 1) coronary plaque vulnerability as assessed by optical coherence tomography (OCT), 2) coronary artery calcium (CAC) by means of computed tomography scan, and 3) aortic wall metabolic activity, as assessed using <sup>18</sup>F-Fluorodeoxyglucose-positron emission tomography (<sup>18</sup>F-FDG-PET). Results: After univariable and multivariable analyses, <sup>18</sup>F-FDG uptake in the descending aorta (DA) was independently associated with a low level of CysC [(Odds Ratio = 0.02; 95%CI 0.0004⁻0.89; p = 0.044; <sup>18</sup>F-FDG uptake measured as averaged maximum target to blood ratio); (Odds Ratio = 0.89; 95%CI 0.82⁻0.98, p = 0.025; <sup>18</sup>F-FDG uptake measured as number of active slices)]. No trend was found for the association between CysC and characteristics of OCT-assessed coronary plaque vulnerability or CAC score. Conclusions: In patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), <sup>18</sup>F-FDG uptake in the DA was associated with a low level of serum CysC. There was no relation between CysC levels and OCT-assessed coronary plaque vulnerability or CAC score. These findings suggest that high levels of CysC may not be considered as independent markers of atherosclerosis.https://www.mdpi.com/2076-3417/9/4/657cystatin C<sup>18</sup>F-fluorodeoxyglucose-positron emission tomographyfrequency domain-optical coherence tomographycoronary artery calcium scorenon-ST-segment elevation acute coronary syndrome |