C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract
Abstract Background Interstitial Cajal cells have been suspected as being the pacemaker cells of smooth muscle motor activity and discharging slow triggering waves in the gut as well as in other organs containing smooth muscles where they are known as interstitial Cajal-like cells (ICLC). The presen...
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doaj-1e34227109d7410382f994feafbefc1f2020-11-24T21:41:21ZengBMCActa Veterinaria Scandinavica1751-01472017-05-015911910.1186/s13028-017-0300-5C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tractMalgorzata Domino0Bartosz Pawlinski1Romuald Zabielski2Zdzislaw Gajewski3Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (WULS-SGGW)Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (WULS-SGGW)Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (WULS-SGGW)Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (WULS-SGGW)Abstract Background Interstitial Cajal cells have been suspected as being the pacemaker cells of smooth muscle motor activity and discharging slow triggering waves in the gut as well as in other organs containing smooth muscles where they are known as interstitial Cajal-like cells (ICLC). The present study describes ICLC localization and density in the porcine oviduct and uterus. Differences in ICLC density were examined using histological, immunohistochemical and immunofluorescent methods and c-kit expression was determined. Results interstitial Cajal-like cells with characteristic morphological and immunological phenotypes were found. Star-like or spindle-shaped cells with very long, moniliform processes were localized in the muscle layers of the oviduct and uterine walls at variable densities that decreased progressively from high in the oviduct to low in the uterus. Conclusions The detailed description of ICLC in the porcine reproductive tract may lead to a better understanding of reproductive tract motility. Our approach is inexpensive and effective for ICLC evaluation and may in the future be applied to clinical diagnosis.http://link.springer.com/article/10.1186/s13028-017-0300-5MyometriumOviductC-kit/CD 117Interstitial Cajal-like cellICLCSow |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Malgorzata Domino Bartosz Pawlinski Romuald Zabielski Zdzislaw Gajewski |
spellingShingle |
Malgorzata Domino Bartosz Pawlinski Romuald Zabielski Zdzislaw Gajewski C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract Acta Veterinaria Scandinavica Myometrium Oviduct C-kit/CD 117 Interstitial Cajal-like cell ICLC Sow |
author_facet |
Malgorzata Domino Bartosz Pawlinski Romuald Zabielski Zdzislaw Gajewski |
author_sort |
Malgorzata Domino |
title |
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract |
title_short |
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract |
title_full |
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract |
title_fullStr |
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract |
title_full_unstemmed |
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract |
title_sort |
c-kit receptor immunopositive interstitial cells (cajal-type) in the porcine reproductive tract |
publisher |
BMC |
series |
Acta Veterinaria Scandinavica |
issn |
1751-0147 |
publishDate |
2017-05-01 |
description |
Abstract Background Interstitial Cajal cells have been suspected as being the pacemaker cells of smooth muscle motor activity and discharging slow triggering waves in the gut as well as in other organs containing smooth muscles where they are known as interstitial Cajal-like cells (ICLC). The present study describes ICLC localization and density in the porcine oviduct and uterus. Differences in ICLC density were examined using histological, immunohistochemical and immunofluorescent methods and c-kit expression was determined. Results interstitial Cajal-like cells with characteristic morphological and immunological phenotypes were found. Star-like or spindle-shaped cells with very long, moniliform processes were localized in the muscle layers of the oviduct and uterine walls at variable densities that decreased progressively from high in the oviduct to low in the uterus. Conclusions The detailed description of ICLC in the porcine reproductive tract may lead to a better understanding of reproductive tract motility. Our approach is inexpensive and effective for ICLC evaluation and may in the future be applied to clinical diagnosis. |
topic |
Myometrium Oviduct C-kit/CD 117 Interstitial Cajal-like cell ICLC Sow |
url |
http://link.springer.com/article/10.1186/s13028-017-0300-5 |
work_keys_str_mv |
AT malgorzatadomino ckitreceptorimmunopositiveinterstitialcellscajaltypeintheporcinereproductivetract AT bartoszpawlinski ckitreceptorimmunopositiveinterstitialcellscajaltypeintheporcinereproductivetract AT romualdzabielski ckitreceptorimmunopositiveinterstitialcellscajaltypeintheporcinereproductivetract AT zdzislawgajewski ckitreceptorimmunopositiveinterstitialcellscajaltypeintheporcinereproductivetract |
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