Recent Advances in Organelle-Targeted Fluorescent Probes

Recent Advances in Organelle-Targeted Fluorescent Probes

Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and tr...

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Main Authors: Na-Eun Choi, Ji-Yu Lee, Eun-Chae Park, Ju-Hee Lee, Jiyoun Lee
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
fluorescence imaging
organelle-targeting
chemical probes
Online Access:https://www.mdpi.com/1420-3049/26/1/217
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spelling doaj-1e45e178352847d7a3ad5c2e8dc502422021-01-05T00:01:11ZengMDPI AGMolecules1420-30492021-01-012621721710.3390/molecules26010217Recent Advances in Organelle-Targeted Fluorescent ProbesNa-Eun Choi0Ji-Yu Lee1Eun-Chae Park2Ju-Hee Lee3Jiyoun Lee4Department of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaDepartment of Next-Generation Applied Science, and Global Medical Science, Sungshin University, Seoul 01133, KoreaRecent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions.https://www.mdpi.com/1420-3049/26/1/217fluorescence imagingorganelle-targetingchemical probes
collection DOAJ
language English
format Article
sources DOAJ
author Na-Eun Choi
Ji-Yu Lee
Eun-Chae Park
Ju-Hee Lee
Jiyoun Lee
spellingShingle Na-Eun Choi
Ji-Yu Lee
Eun-Chae Park
Ju-Hee Lee
Jiyoun Lee
Recent Advances in Organelle-Targeted Fluorescent Probes
Molecules
fluorescence imaging
organelle-targeting
chemical probes
author_facet Na-Eun Choi
Ji-Yu Lee
Eun-Chae Park
Ju-Hee Lee
Jiyoun Lee
author_sort Na-Eun Choi
title Recent Advances in Organelle-Targeted Fluorescent Probes
title_short Recent Advances in Organelle-Targeted Fluorescent Probes
title_full Recent Advances in Organelle-Targeted Fluorescent Probes
title_fullStr Recent Advances in Organelle-Targeted Fluorescent Probes
title_full_unstemmed Recent Advances in Organelle-Targeted Fluorescent Probes
title_sort recent advances in organelle-targeted fluorescent probes
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-01-01
description Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions.
topic fluorescence imaging
organelle-targeting
chemical probes
url https://www.mdpi.com/1420-3049/26/1/217
work_keys_str_mv AT naeunchoi recentadvancesinorganelletargetedfluorescentprobes
AT jiyulee recentadvancesinorganelletargetedfluorescentprobes
AT eunchaepark recentadvancesinorganelletargetedfluorescentprobes
AT juheelee recentadvancesinorganelletargetedfluorescentprobes
AT jiyounlee recentadvancesinorganelletargetedfluorescentprobes
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