In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
Lrig proteins are conserved transmembrane proteins that modulate a variety of signaling pathways from worm to humans. In mammals, there are three family members - Lrig1, Lrig2, and Lrig3--that are defined by closely related extracellular domains with a similar arrangement of leucine rich repeats and...
Main Authors: | Tony Del Rio, Allison M Nishitani, Wei-Ming Yu, Lisa V Goodrich |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3784559?pdf=render |
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