Curcumin and Endometriosis
Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative str...
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doaj-1e637083d78e46b9a92194200c08a7512020-11-25T02:33:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-03-01212440244010.3390/ijms21072440Curcumin and EndometriosisAlexandre Vallée0Yves Lecarpentier1Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, AP-HP, Paris-Descartes University, 75004 Paris, FranceCentre de Recherche Clinique, Grand Hôpital de l’Est Francilien (GHEF), 77100 Meaux, FranceEndometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.https://www.mdpi.com/1422-0067/21/7/2440endometriosiscurcumininflammationoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandre Vallée Yves Lecarpentier |
spellingShingle |
Alexandre Vallée Yves Lecarpentier Curcumin and Endometriosis International Journal of Molecular Sciences endometriosis curcumin inflammation oxidative stress |
author_facet |
Alexandre Vallée Yves Lecarpentier |
author_sort |
Alexandre Vallée |
title |
Curcumin and Endometriosis |
title_short |
Curcumin and Endometriosis |
title_full |
Curcumin and Endometriosis |
title_fullStr |
Curcumin and Endometriosis |
title_full_unstemmed |
Curcumin and Endometriosis |
title_sort |
curcumin and endometriosis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-03-01 |
description |
Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis. |
topic |
endometriosis curcumin inflammation oxidative stress |
url |
https://www.mdpi.com/1422-0067/21/7/2440 |
work_keys_str_mv |
AT alexandrevallee curcuminandendometriosis AT yveslecarpentier curcuminandendometriosis |
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