DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells.
DMH1(4-[6-(4-Isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a compound C analogue with the structural modifications at the 3- and 6-positions in pyrazolo[1,5-a]pyrimidine backbone. Compound C was reported to inhibit both AMPK and Akt. Our preliminary work found that DMH1 activated Ak...
Main Authors: | Xin Xie, Xiao-Ming Xu, Na Li, Yong-Hui Zhang, Yu Zhao, Chun-Yan Ma, De-Li Dong |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4172596?pdf=render |
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