Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope

Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope

Abstract Over the past decade, therapeutic messenger RNAs (mRNAs) have emerged as a highly promising new class of drugs for protein replacement therapies. Due to the recent developments, the incorporation of modified nucleotides in synthetic mRNAs can lead to maximizing protein expression and reduci...

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Bibliographic Details
Main Authors: Cynthia Aslan, Seyed Hossein Kiaie, Naime Majidi Zolbanin, Parisa Lotfinejad, Reihaneh Ramezani, Fatah Kashanchi, Reza Jafari
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Biotechnology
Subjects:
mRNA therapy
Drug delivery
Exosomes
Extracellular vesicles
Immunogenicity
Toxicity
Online Access:https://doi.org/10.1186/s12896-021-00683-w

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