Graphene reinforced polyether ether ketone nanocomposites for bone repair applications
To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene nanoplatelet (G) reinforced PEEK with different filler weight concentrations (0.1%–5%) through injection moulding. The mechanical properties, surface morpholo...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-08-01
|
Series: | Polymer Testing |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941821002257 |
id |
doaj-1e7fe61a3e0042c38267396b7c60fc61 |
---|---|
record_format |
Article |
spelling |
doaj-1e7fe61a3e0042c38267396b7c60fc612021-07-25T04:40:37ZengElsevierPolymer Testing0142-94182021-08-01100107276Graphene reinforced polyether ether ketone nanocomposites for bone repair applicationsNan Jiang0Peijie Tan1Miaomiao He2Jie Zhang3Dan Sun4Songsong Zhu5State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology and the Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology and the Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology and the Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology and the Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610041, ChinaAdvanced Composite Research Group (ACRG), School of Mechanical and Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, UKState Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology and the Research Center for Nano Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610041, China; Corresponding author. State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University Chengdu, Sichuan, 610064, China.To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene nanoplatelet (G) reinforced PEEK with different filler weight concentrations (0.1%–5%) through injection moulding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized. The biocompatibility has been assessed in vitro and the bone repair function of the composite implants have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants.http://www.sciencedirect.com/science/article/pii/S0142941821002257Polyether ether ketonePEEKGrapheneNanocompositesOsteointegrationBone repair |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nan Jiang Peijie Tan Miaomiao He Jie Zhang Dan Sun Songsong Zhu |
spellingShingle |
Nan Jiang Peijie Tan Miaomiao He Jie Zhang Dan Sun Songsong Zhu Graphene reinforced polyether ether ketone nanocomposites for bone repair applications Polymer Testing Polyether ether ketone PEEK Graphene Nanocomposites Osteointegration Bone repair |
author_facet |
Nan Jiang Peijie Tan Miaomiao He Jie Zhang Dan Sun Songsong Zhu |
author_sort |
Nan Jiang |
title |
Graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
title_short |
Graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
title_full |
Graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
title_fullStr |
Graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
title_full_unstemmed |
Graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
title_sort |
graphene reinforced polyether ether ketone nanocomposites for bone repair applications |
publisher |
Elsevier |
series |
Polymer Testing |
issn |
0142-9418 |
publishDate |
2021-08-01 |
description |
To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene nanoplatelet (G) reinforced PEEK with different filler weight concentrations (0.1%–5%) through injection moulding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized. The biocompatibility has been assessed in vitro and the bone repair function of the composite implants have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants. |
topic |
Polyether ether ketone PEEK Graphene Nanocomposites Osteointegration Bone repair |
url |
http://www.sciencedirect.com/science/article/pii/S0142941821002257 |
work_keys_str_mv |
AT nanjiang graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications AT peijietan graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications AT miaomiaohe graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications AT jiezhang graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications AT dansun graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications AT songsongzhu graphenereinforcedpolyetheretherketonenanocompositesforbonerepairapplications |
_version_ |
1721283847651328000 |