A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus
Aim. To describe a case of arterial thrombosis with a thrombus that had atypical composition due to profound pathological changes in the cellular and protein composition of the blood. Methods. Scanning electron microscopy of an ex vivo thrombus extracted from the common femoral artery. Results...
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doaj-1e83813027c140f8849e370510e152012020-11-24T23:02:01ZrusECO-vectorKazanskij Medicinskij Žurnal0368-48142587-93592018-12-0199699499710.17816/KMJ2018-9949530A case of arterial thrombosis with formation of an atypical fibrin-rich thrombusR R Khismatullin0A Z Shakirova1A D Peshkova2A N Khuziakhmedov3S M Khizriev4R I Litvinov5Kazan State Medical UniversityKazan State Medical University; Departmental Clinical Hospital of Station KazanKazan (Volga Region) Federal UniversityCity Clinical Hospital № 7City Clinical Hospital № 7Kazan (Volga Region) Federal University; University of Pennsylvania School of MedicineAim. To describe a case of arterial thrombosis with a thrombus that had atypical composition due to profound pathological changes in the cellular and protein composition of the blood. Methods. Scanning electron microscopy of an ex vivo thrombus extracted from the common femoral artery. Results. In the absence of platelets and leukocytes there was a significant prevalence of fibrin over other blood components in all layers of the arterial thrombus. There were no morphological signs of intravital contraction (retraction) characteristic for thrombi: single erythrocytes were not exposed compressive deformation, redistribution of fibrin and platelets within the thrombus toward the periphery. Formation of the atypical arterial thrombus in the vessel with atherosclerotic vessel damage is probably due to association with severe hyperfibrinogenemia and thrombocytopenia. Conclusion. The structure of a thrombus depends not only on its vascular location (arterial or venous), but also on the cellular and protein composition of the blood. These factors support diversification of antithrombotic therapy, considering composition and properties of thrombi irrespective of the place and hemodynamic conditions of their formation.https://kazanmedjournal.ru/kazanmedj/article/viewFile/10518/8330arterial thrombusfibrin |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
R R Khismatullin A Z Shakirova A D Peshkova A N Khuziakhmedov S M Khizriev R I Litvinov |
spellingShingle |
R R Khismatullin A Z Shakirova A D Peshkova A N Khuziakhmedov S M Khizriev R I Litvinov A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus Kazanskij Medicinskij Žurnal arterial thrombus fibrin |
author_facet |
R R Khismatullin A Z Shakirova A D Peshkova A N Khuziakhmedov S M Khizriev R I Litvinov |
author_sort |
R R Khismatullin |
title |
A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
title_short |
A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
title_full |
A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
title_fullStr |
A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
title_full_unstemmed |
A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
title_sort |
case of arterial thrombosis with formation of an atypical fibrin-rich thrombus |
publisher |
ECO-vector |
series |
Kazanskij Medicinskij Žurnal |
issn |
0368-4814 2587-9359 |
publishDate |
2018-12-01 |
description |
Aim. To describe a case of arterial thrombosis with a thrombus that had atypical composition due to profound pathological changes in the cellular and protein composition of the blood.
Methods. Scanning electron microscopy of an ex vivo thrombus extracted from the common femoral artery.
Results. In the absence of platelets and leukocytes there was a significant prevalence of fibrin over other blood components in all layers of the arterial thrombus. There were no morphological signs of intravital contraction (retraction) characteristic for thrombi: single erythrocytes were not exposed compressive deformation, redistribution of fibrin and platelets within the thrombus toward the periphery. Formation of the atypical arterial thrombus in the vessel with atherosclerotic vessel damage is probably due to association with severe hyperfibrinogenemia and thrombocytopenia.
Conclusion. The structure of a thrombus depends not only on its vascular location (arterial or venous), but also on the cellular and protein composition of the blood. These factors support diversification of antithrombotic therapy, considering composition and properties of thrombi irrespective of the place and hemodynamic conditions of their formation. |
topic |
arterial thrombus fibrin |
url |
https://kazanmedjournal.ru/kazanmedj/article/viewFile/10518/8330 |
work_keys_str_mv |
AT rrkhismatullin acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT azshakirova acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT adpeshkova acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT ankhuziakhmedov acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT smkhizriev acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT rilitvinov acaseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT rrkhismatullin caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT azshakirova caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT adpeshkova caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT ankhuziakhmedov caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT smkhizriev caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus AT rilitvinov caseofarterialthrombosiswithformationofanatypicalfibrinrichthrombus |
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1725637758839422976 |