Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.
We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellula...
Main Authors: | Kiminori Sada, Takeshi Nishikawa, Daisuke Kukidome, Tomoaki Yoshinaga, Nobuhiro Kajihara, Kazuhiro Sonoda, Takafumi Senokuchi, Hiroyuki Motoshima, Takeshi Matsumura, Eiichi Araki |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4934928?pdf=render |
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