FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons...
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2017-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14741 |
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doaj-1e9c2716f18a4d80882bcb92f54bc7922021-05-11T07:46:03ZengNature Publishing GroupNature Communications2041-17232017-03-018111110.1038/ncomms14741FUS affects circular RNA expression in murine embryonic stem cell-derived motor neuronsLorenzo Errichelli0Stefano Dini Modigliani1Pietro Laneve2Alessio Colantoni3Ivano Legnini4Davide Capauto5Alessandro Rosa6Riccardo De Santis7Rebecca Scarfò8Giovanna Peruzzi9Lei Lu10Elisa Caffarelli11Neil A. Shneider12Mariangela Morlando13Irene Bozzoni14Center for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia UniversityCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia UniversityDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaThe RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.https://doi.org/10.1038/ncomms14741 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni |
spellingShingle |
Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons Nature Communications |
author_facet |
Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni |
author_sort |
Lorenzo Errichelli |
title |
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons |
title_short |
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons |
title_full |
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons |
title_fullStr |
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons |
title_full_unstemmed |
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons |
title_sort |
fus affects circular rna expression in murine embryonic stem cell-derived motor neurons |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-03-01 |
description |
The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs. |
url |
https://doi.org/10.1038/ncomms14741 |
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