FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons...

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Main Authors: Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfò, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando, Irene Bozzoni
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14741
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spelling doaj-1e9c2716f18a4d80882bcb92f54bc7922021-05-11T07:46:03ZengNature Publishing GroupNature Communications2041-17232017-03-018111110.1038/ncomms14741FUS affects circular RNA expression in murine embryonic stem cell-derived motor neuronsLorenzo Errichelli0Stefano Dini Modigliani1Pietro Laneve2Alessio Colantoni3Ivano Legnini4Davide Capauto5Alessandro Rosa6Riccardo De Santis7Rebecca Scarfò8Giovanna Peruzzi9Lei Lu10Elisa Caffarelli11Neil A. Shneider12Mariangela Morlando13Irene Bozzoni14Center for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia UniversityCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaDepartment of Neurology, Center for Motor Neuron Biology and Disease, Columbia UniversityDeparment of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of RomeCenter for Life Nano Science@Sapienza, Istituto Italiano di TecnologiaThe RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.https://doi.org/10.1038/ncomms14741
collection DOAJ
language English
format Article
sources DOAJ
author Lorenzo Errichelli
Stefano Dini Modigliani
Pietro Laneve
Alessio Colantoni
Ivano Legnini
Davide Capauto
Alessandro Rosa
Riccardo De Santis
Rebecca Scarfò
Giovanna Peruzzi
Lei Lu
Elisa Caffarelli
Neil A. Shneider
Mariangela Morlando
Irene Bozzoni
spellingShingle Lorenzo Errichelli
Stefano Dini Modigliani
Pietro Laneve
Alessio Colantoni
Ivano Legnini
Davide Capauto
Alessandro Rosa
Riccardo De Santis
Rebecca Scarfò
Giovanna Peruzzi
Lei Lu
Elisa Caffarelli
Neil A. Shneider
Mariangela Morlando
Irene Bozzoni
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
Nature Communications
author_facet Lorenzo Errichelli
Stefano Dini Modigliani
Pietro Laneve
Alessio Colantoni
Ivano Legnini
Davide Capauto
Alessandro Rosa
Riccardo De Santis
Rebecca Scarfò
Giovanna Peruzzi
Lei Lu
Elisa Caffarelli
Neil A. Shneider
Mariangela Morlando
Irene Bozzoni
author_sort Lorenzo Errichelli
title FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_short FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_full FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_fullStr FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_full_unstemmed FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_sort fus affects circular rna expression in murine embryonic stem cell-derived motor neurons
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-03-01
description The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.
url https://doi.org/10.1038/ncomms14741
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