Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO<sub>2</sub>) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patien...

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Main Authors: Wagner Jorge Ribeiro Domingues, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato, Nelson Wolosker, Antônio Eduardo Zerati, Pedro Puech-Leão, Daniel Boari Coelho, Pollyana Mayara Nunhes, André Alberto Moliterno, Ademar Avelar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Nutrients
Subjects:
intermittent claudication
mobility limitation
dietary supplements
Online Access:https://www.mdpi.com/2072-6643/13/1/149
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spelling doaj-1ea46cb986e04b2fb9cb66ca065e54262021-01-06T00:00:16ZengMDPI AGNutrients2072-66432021-01-011314914910.3390/nu13010149Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical TrialWagner Jorge Ribeiro Domingues0Raphael Mendes Ritti-Dias1Gabriel Grizzo Cucato2Nelson Wolosker3Antônio Eduardo Zerati4Pedro Puech-Leão5Daniel Boari Coelho6Pollyana Mayara Nunhes7André Alberto Moliterno8Ademar Avelar9Institute of Social Sciences Education and Zootechnics, Federal University of Amazonas, Manaus 69152-240, BrazilPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, Sao Paulo 03155-000, BrazilDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8PP, UKHospital Israelita Albert Einstein, Sao Paulo 05652-900, BrazilCancer Institute of Sao Paulo, Sao Paulo 01246-000, BrazilFaculty of Medicine Sao Paulo University, Sao Paulo 04021-001, BrazilCenter for Engineering, Modeling and Applied Social Sciences (CECS), Federal University of ABC, São Bernardo do Campo 09606-070, BrazilDepartment of Physical Education, State University of Maringa, Maringa 87020-900, BrazilDepartment of Physical Education, State University of Maringa, Maringa 87020-900, BrazilDepartment of Physical Education, State University of Maringa, Maringa 87020-900, BrazilThe aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO<sub>2</sub>) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, <i>n</i> = 15) or creatine monohydrate (Cr, <i>n</i> = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO<sub>2</sub> was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was <i>p</i> < 0.05. No significant differences were found for function capacity (total walking distance (PLA: pre 389 ± 123 m vs. post loading 413 ± 131 m vs. post maintenance 382 ± 99 m; Cr: pre 373 ± 149 m vs. post loading 390 ± 115 m vs. post maintenance 369 ± 115 m, <i>p</i> = 0.170) and the calf muscle StO<sub>2</sub> parameters (<i>p</i> > 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO<sub>2</sub> parameters in patients with symptomatic PAD.https://www.mdpi.com/2072-6643/13/1/149intermittent claudicationmobility limitationdietary supplements
collection DOAJ
language English
format Article
sources DOAJ
author Wagner Jorge Ribeiro Domingues
Raphael Mendes Ritti-Dias
Gabriel Grizzo Cucato
Nelson Wolosker
Antônio Eduardo Zerati
Pedro Puech-Leão
Daniel Boari Coelho
Pollyana Mayara Nunhes
André Alberto Moliterno
Ademar Avelar
spellingShingle Wagner Jorge Ribeiro Domingues
Raphael Mendes Ritti-Dias
Gabriel Grizzo Cucato
Nelson Wolosker
Antônio Eduardo Zerati
Pedro Puech-Leão
Daniel Boari Coelho
Pollyana Mayara Nunhes
André Alberto Moliterno
Ademar Avelar
Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
Nutrients
intermittent claudication
mobility limitation
dietary supplements
author_facet Wagner Jorge Ribeiro Domingues
Raphael Mendes Ritti-Dias
Gabriel Grizzo Cucato
Nelson Wolosker
Antônio Eduardo Zerati
Pedro Puech-Leão
Daniel Boari Coelho
Pollyana Mayara Nunhes
André Alberto Moliterno
Ademar Avelar
author_sort Wagner Jorge Ribeiro Domingues
title Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
title_short Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
title_full Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
title_fullStr Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
title_full_unstemmed Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial
title_sort effect of creatine supplementation on functional capacity and muscle oxygen saturation in patients with symptomatic peripheral arterial disease: a pilot study of a randomized, double-blind placebo-controlled clinical trial
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2021-01-01
description The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO<sub>2</sub>) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, <i>n</i> = 15) or creatine monohydrate (Cr, <i>n</i> = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO<sub>2</sub> was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was <i>p</i> < 0.05. No significant differences were found for function capacity (total walking distance (PLA: pre 389 ± 123 m vs. post loading 413 ± 131 m vs. post maintenance 382 ± 99 m; Cr: pre 373 ± 149 m vs. post loading 390 ± 115 m vs. post maintenance 369 ± 115 m, <i>p</i> = 0.170) and the calf muscle StO<sub>2</sub> parameters (<i>p</i> > 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO<sub>2</sub> parameters in patients with symptomatic PAD.
topic intermittent claudication
mobility limitation
dietary supplements
url https://www.mdpi.com/2072-6643/13/1/149
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