The Function of Autophagy in Neurodegenerative Diseases
Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neuron...
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doaj-1ea80606c086497bb69ccb21174dc7932020-11-24T20:43:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-11-011611267972681210.3390/ijms161125990ijms161125990The Function of Autophagy in Neurodegenerative DiseasesYoshimitsu Kiriyama0Hiromi Nochi1School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, JapanSchool of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, JapanMacroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases.http://www.mdpi.com/1422-0067/16/11/25990autophagymitophagyAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseaseALSSENDA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoshimitsu Kiriyama Hiromi Nochi |
spellingShingle |
Yoshimitsu Kiriyama Hiromi Nochi The Function of Autophagy in Neurodegenerative Diseases International Journal of Molecular Sciences autophagy mitophagy Alzheimer’s disease Parkinson’s disease Huntington’s disease ALS SENDA |
author_facet |
Yoshimitsu Kiriyama Hiromi Nochi |
author_sort |
Yoshimitsu Kiriyama |
title |
The Function of Autophagy in Neurodegenerative Diseases |
title_short |
The Function of Autophagy in Neurodegenerative Diseases |
title_full |
The Function of Autophagy in Neurodegenerative Diseases |
title_fullStr |
The Function of Autophagy in Neurodegenerative Diseases |
title_full_unstemmed |
The Function of Autophagy in Neurodegenerative Diseases |
title_sort |
function of autophagy in neurodegenerative diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-11-01 |
description |
Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases. |
topic |
autophagy mitophagy Alzheimer’s disease Parkinson’s disease Huntington’s disease ALS SENDA |
url |
http://www.mdpi.com/1422-0067/16/11/25990 |
work_keys_str_mv |
AT yoshimitsukiriyama thefunctionofautophagyinneurodegenerativediseases AT hirominochi thefunctionofautophagyinneurodegenerativediseases AT yoshimitsukiriyama functionofautophagyinneurodegenerativediseases AT hirominochi functionofautophagyinneurodegenerativediseases |
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1716820009466986496 |